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首页> 外文期刊>Current sports medicine reports. >Beyond hypoestrogenism in amenorrheic athletes: energy deficiency as a contributing factor for bone loss.
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Beyond hypoestrogenism in amenorrheic athletes: energy deficiency as a contributing factor for bone loss.

机译：除闭经运动员外，还存在雌激素不足的问题：能量缺乏是造成骨质流失的一个因素。

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摘要

The etiology of amenorrhea in exercising women is linked to a mismatch between caloric intake and high levels of exercise energy expenditure that results in a chronic energy deficit. This in turn stimulates compensatory mechanisms such as weight loss, metabolic hormone alterations, or energy conservation that subsequently causes a central suppression of reproductive function and concomitant hypoestrogenism. This suppression of reproductive function is associated with stress fractures, loss of bone mineral density, the failure to achieve peak bone mass, osteopenia, and osteoporosis. It has generally been accepted that the chronic hypoestrogenism is the major cause of bone loss in exercising women. However, the effects of food restriction and energy deficiency on bone mineral density likely represents an estrogen-independent mechanism for bone loss that involves some of the metabolic-related hormones altered with exercise-associated amenorrhea. These hormones (IGF-1 and leptin) play an important role in modulating bone turnover and bone mineral density in these women.
机译：运动妇女闭经的病因与热量摄入和高水平运动能量消耗之间的不匹配有关，导致长期能量缺乏。反过来，这会刺激补偿机制，例如体重减轻，代谢激素改变或能量守恒，继而引起生殖功能的中心抑制和伴随的雌激素不足。生殖功能的这种抑制与应力性骨折，骨矿物质密度的损失，无法达到峰值骨量，骨质减少和骨质疏松有关。公认的是，慢性雌激素低下是锻炼女性骨质流失的主要原因。但是，食物限制和能量不足对骨矿物质密度的影响可能代表了一种与雌激素无关的骨质流失机制，其中涉及一些与运动相关的闭经而改变的代谢相关激素。这些激素（IGF-1和瘦素）在调节这些女性的骨转换和骨矿物质密度中起重要作用。

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