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首页> 外文期刊>Current Science: A Fortnightly Journal of Research >Compensatory effects of medicinal plants of Pakistan upon prolongation of coagulation assays induced by Naja naja karachiensis bite
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Compensatory effects of medicinal plants of Pakistan upon prolongation of coagulation assays induced by Naja naja karachiensis bite

机译：巴基斯坦眼镜蛇对Naja naja karachiensis叮咬诱导的凝血分析时间延长的补偿作用

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摘要

The present study was carried out to evaluate 28 medicinal plants of Pakistan having folklore claims to neutralize coagulopathy induced by Naja naja karachiensis bite in comparison with standard antidote. Venom was tested on citrated human plasma to determine its effect on prothrombin time (PT), activated partial thromboplastin time (aPTT) and thrombin time (TT). Snake venom (200 mu g/ml) was found to delay PT (13 +/- 0.57 to 23 +/- 0.57 sec), aPTT (35 +/- 1.52 to 48 +/- 2.0 sec) and TT (13 +/- 0.57 to 33 +/- 0.57 sec) within 4.5% coefficient of variance. Prolongation of PT and TT suggested the presence of thrombin-like or plasminogen activating enzymes. Methanolic plant extracts (5 mu g/ml) were considered as effective standard antidote. Enicostemma hyssoinfolium (Willd.) Verdoorn (PT = 22 +/- 0.57 sec, aPTT = 36 +/- 1.00 sec, TT = 19 +/- 0.57 sec) and Stenolobium stans (L) D. Don (PT = 16 +/- 0.57 sec, aPTT = 36 +/- 0.57 sec, TT = 29 +/- 0.57 sec) were considered the most protective (>= 70%, but <= 92%) from the rest of the listed medicinal plants. Nevertheless, further studies are required for identification and segregation of bioactive constituent(s) as an alternate and cheap source to treat anticoagulation.
机译：进行本研究以评估巴基斯坦的28种具有民间传说的药用植物，该植物与标准解毒剂相比具有中和因眼镜蛇眼镜蛇咬伤而诱发的凝血病的能力。在柠檬酸化的人血浆上测试了毒液，以确定其对凝血酶原时间（PT），活化的部分凝血活酶时间（aPTT）和凝血酶时间（TT）的影响。发现蛇毒（200μg / ml）延迟PT（13 +/- 0.57至23 +/- 0.57秒），aPTT（35 +/- 1.52至48 +/- 2.0秒）和TT（13 + / -0.57到33 +/- 0.57秒）在4.5％的变异系数内。 PT和TT延长表明存在凝血酶样或纤溶酶原激活酶。甲醇植物提取物（5微克/毫升）被认为是有效的标准解毒剂。腐烂的Enicostemma hyssoinfolium（Willd。）Verdoorn（PT = 22 +/- 0.57秒，aPTT = 36 +/- 1.00秒，TT = 19 +/- 0.57秒）和Stenolobium stans（L）D.Don（PT = 16 + / -0.57秒，aPTT = 36 +/- 0.57秒，TT = 29 +/- 0.57秒）被认为是其余列出的药用植物中最具保护性的（> = 70％，但<= 92％）。然而，需要进一步的研究以鉴定和分离生物活性成分作为治疗抗凝的另一种廉价来源。

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