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首页> 外文期刊>Current Science: A Fortnightly Journal of Research >Cancer modulation by glucosinolates: A review [Review]
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Cancer modulation by glucosinolates: A review [Review]

机译：芥子油苷对癌症的调节作用：综述[综述]

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摘要

Glucosinolates (GLS) are a group of plant thioglucosides present in plants of Cruciferae family. They are well known for their toxic effects (mainly as goitrogens) in both man and animals at high doses. In contrast at subtoxic doses, their hydrolytic and metabolic products act as chemoprotective agents against chemically-induced carcinogens by blocking the initiation of tumours in a variety of rodent tissues, viz, liver, colon, mammary gland, pancreas, etc. They exhibit their effect by inducing Phase I and Phase II enzymes, inhibiting the enzyme activation, modifying the steroid hormone metabolism and protecting against oxidative damages. Acid condensation products (like DIM) are more effective than their parent compounds (like 13C). Anticarcinogenesis caused by GLS is reviewed here. [References: 87]
机译：芥子油苷（GLS）是十字花科植物中存在的一组植物硫苷。它们以高剂量对人和动物的毒性作用（主要是甲状腺激素）而闻名。相比之下，在亚毒性剂量下，它们的水解和代谢产物通过阻止各种啮齿动物组织（即，肝脏，结肠，结肠，乳腺，胰腺等）中肿瘤的发生，充当化学诱导的致癌物的化学保护剂。它们发挥了作用通过诱导I期和II期酶，抑制酶的活化，改变类固醇激素的代谢并防止氧化损伤。酸缩合产物（如DIM）比其母体化合物（如13C）更有效。本文综述了由GLS引起的抗癌作用。 [参考：87]

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