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首页> 外文期刊>Current Science: A Fortnightly Journal of Research >Diabetic retinopathy: Molecular mechanisms, present regime of treatmentand future perspectives [Review]
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Diabetic retinopathy: Molecular mechanisms, present regime of treatmentand future perspectives [Review]

机译：糖尿病性视网膜病：分子机制，目前的治疗方案和未来展望[综述]

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摘要

Diabetes mellitus (DM) has become a common ease with serious complications. One of the most devastating microvascular complications of DM is diabetic retinopathy (DR), Over the last decade considerable progress has been made in the understanding of the pathogenesis of DR, and several factors have been implicated in its pathogenesis, These include non-enzymatic glycation, glycoxidation, accumulation of advanced glycation end-products, free radical mediated protein damage, up-regulation of matrix metalloproteinases, elaboration of growth factors and secretion of adhesion molecules in the vascular endothelium, The exact molecules involved and the precise mechanism of their interaction in the development of retinopathy are presented here. Also discussed are the conventional, and molecular methods of treatment for DR and the growing need for the development of a novel, pharmacological therapeutic regime.
机译：糖尿病（DM）已成为一种常见的疾病，伴有严重的并发症。糖尿病最严重的微血管并发症之一是糖尿病性视网膜病（DR），在过去的十年中，人们对DR的发病机理有了相当大的了解，并且其发病机理涉及多个因素，包括非酶促糖化，糖氧化，晚期糖基化终产物的积累，自由基介导的蛋白质损伤，基质金属蛋白酶的上调，生长因子的加工和血管内皮细胞黏附分子的分泌，涉及的确切分子及其相互作用的精确机制此处介绍了视网膜病变的发展。还讨论了用于DR的常规和分子治疗方法以及对开发新的药理学治疗方案的日益增长的需求。

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