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首页> 外文期刊>Current Science: A Fortnightly Journal of Research >In vivo study on dual-signal hypothesis and its correlation to immuneresponse using mycobacterial antigen
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In vivo study on dual-signal hypothesis and its correlation to immuneresponse using mycobacterial antigen

机译：分枝杆菌抗原对双信号假说及其与免疫反应相关性的体内研究

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摘要

Antigens have the innate ability to trigger both mitosis and apoptosis simultaneously (dual-signal hypothesis). The fate of the cell depends on the dosage and duration of the trigger. In the present study, dual-signal hypothesis was tested in a murine model using a mycobacterial antigen (purified protein derivative-PPD). As a positive control, E. coli-lipopolysaccharide (LPS) was used. The results were correlated with the humoral immune response. Our results showed that PPD had induced apoptosis in thymus only (after 7 days), while LPS had induced apoptosis in both thymus and bone marrow (after 18 h). Further, the plasma from PPD-treated animals had higher levels of Mycobacterium tuberculosis-specific antibodies and also recognized a few Al. tuberculosis-specific antigens on immunoblot. To conclude, PPD has induced thymic apoptosis and has also elicited a potent antibody response.
机译：抗原具有同时触发有丝分裂和凋亡的先天能力（双信号假设）。细胞的命运取决于触发的剂量和持续时间。在本研究中，使用分枝杆菌抗原（纯化的蛋白衍生物-PPD）在鼠模型中测试了双信号假设。作为阳性对照，使用大肠杆菌脂多糖（LPS）。结果与体液免疫反应相关。我们的结果表明，PPD仅诱导胸腺细胞凋亡（7天后），而LPS诱导胸腺和骨髓细胞凋亡（18 h后）。此外，PPD处理动物的血浆中结核分枝杆菌特异性抗体的含量较高，并且还可以识别少量Al。免疫印迹上的结核特异性抗原。总而言之，PPD诱导了胸腺细胞凋亡，并且还引发了有效的抗体反应。

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