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首页> 外文期刊>The Journal of Chemical Physics >Temperature response of soft ionizable polymer nanoparticles
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Temperature response of soft ionizable polymer nanoparticles

机译：软可电离聚合物纳米粒子的温度响应

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The temperature response of luminescent ionizable polymers confined into far from equilibrium nanoparticles without chemical links was studied using molecular dynamics simulations. These nanoparticles, often referred to as polydots, are emerging as a promising tool for nanomedicine. Incorporating ionizable groups into these polymers enables biofunctionality; however, they also affect the delicate balance of interactions that hold these nanoparticles together. Here polydots formed by a model polymer dialkyl p-phenylene ethynylene with varying number of carboxylate groups along the polymer backbone were probed. We find that increasing temperature affects neutral and charged polydots differently, where neutral polydots exhibit a transition above which their structure becomes dynamic and they unravel. The dependence of the transition temperature on the surface to volume ratio of these polydots is much stronger than what has previously been observed in polymeric thin films. Charged polydots become dynamic enabling migration of the ionizable groups toward the particle interface, while retaining the overall particle shape. Published by AIP Publishing.
机译：使用分子动力学模拟研究了不受化学链接的不含化学链接的平衡纳米颗粒的潮声可电离聚合物的温度响应。这些纳米颗粒通常被称为多点，作为纳米胺的有希望的工具。将可电离基团掺入这些聚合物中使能生物功能性;然而，它们也会影响将这些纳米颗粒的相互作用的微妙平衡。这里探测了由模型聚合物二烷基对苯基 - 苯基乙炔乙炔的多蛋白探测，沿着聚合物主链不同数量的羧酸盐​​组。我们发现越来越多的温度不同地影响中性和充电的多点，其中中性多点表现出上方的过渡，它们的结构变得动态并且它们衰落。过渡温度对这些多点的表面比的转变温度的依赖性远比先前在聚合物薄膜中观察到的依赖性。带电多点变得动态使可电离基团迁移到颗粒界面，同时保持整体颗粒形状。通过AIP发布发布。

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