Fluorescence resonance energy transfer dynamics during protein folding: Evidence of multistage folding kinetics

Mukherjee A; Bagchi B

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Fluorescence resonance energy transfer dynamics during protein folding: Evidence of multistage folding kinetics

机译：蛋白质折叠过程中的荧光共振能量转移动力学：多阶段折叠动力学的证据

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Fluorescence resonance energy transfer (FRET) during folding of a model protein, HP-36, is investigated by Brownian dynamics simulation. Computer simulations of this protein show that folding kinetics is non-exponential and multistage, after a fast initial hydrophobic collapse. This multistage dynamics can be captured in FRET with a suitably chosen donor-acceptor pair. In particular, we find that FRET can be sensitive to late stages of changes in the radius of gyration which is found to occur for this model protein. This late stage dynamics is driven by changes in the topological pair contact formation.

机译：通过布朗动力学模拟研究了模型蛋白HP-36折叠过程中的荧光共振能量转移（FRET）。这种蛋白质的计算机模拟表明，在快速的初始疏水塌陷之后，折叠动力学是非指数的并且是多阶段的。可以使用适当选择的供体-受体对在FRET中捕获这种多阶段动力学。尤其是，我们发现FRET可能对这种模型蛋白发生的回转半径变化的后期敏感。后期动力学是由拓扑对接触形成的变化驱动的。

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《Current Science: A Fortnightly Journal of Research》 |2003年第1期|共5页
作者
Mukherjee A; Bagchi B;
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正文语种 eng
中图分类自然科学现状及发展;
关键词
Electron-transfer; Chain molecules; Random coil; Simulation; Dependence; Landscape; Helix;

机译：电子转移链分子随机线圈模拟依赖风景横向螺旋;

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1. Fluorescence resonance energy transfer dynamics during protein folding: Evidence of multistage folding kinetics [J] . Mukherjee A, Bagchi B Current Science: A Fortnightly Journal of Research . 2003,第1期

机译：蛋白质折叠过程中的荧光共振能量转移动力学：多阶段折叠动力学的证据
2. Single-Molecule Fluorescence Resonance Energy Transfer Studies of the Human Telomerase RNA Pseudoknot: Temperature-/Urea-Dependent Folding Kinetics and Thermodynamics [J] . Erik D. Holmstrom, David J. Nesbitt The journal of physical chemistry, B. Condensed matter, materials, surfaces, interfaces & biophysical . 2014,第14期

机译：人类端粒酶RNA假结的单分子荧光共振能量转移研究：温度/尿素依赖性折叠动力学和热力学。
3. Single-Molecule Fluorescence Resonance Energy Transfer Studies of the Human Telomerase RNA Pseudoknot: Temperature-/Urea-Dependent Folding Kinetics and Thermodynamics [J] . Erik D. Holmstrom, David J. Nesbitt The journal of physical chemistry, B. Condensed matter, materials, surfaces, interfaces & biophysical . 2014,第14期

机译：人类端粒酶RNA假结的单分子荧光共振能量转移研究：温度/尿素依赖性折叠动力学和热力学。
4. Extracting protein folding kinetics in single-pair fluorescence resonance energy transfer experiment based on wavelet analysis [C] . Guangcun Shan, Wei Huang International Congress on High-Speed Photography and Photonics . 2007

机译：基于小波分析的单对荧光共振能量转移实验中蛋白质折叠动力学的提取
5. Thermodynamic and kinetic analyses of stable non-native folded states in protein folding reactions [D] . Svensson, Anna-Karin Elisabeth 2004

机译：蛋白质折叠反应中稳定非天然折叠态的热力学和动力学分析
6. Correction to Single-Molecule FluorescenceResonance Energy Transfer Studies of the Human Telomerase RNA Pseudoknot:Temperature-/Urea-Dependent Folding Kinetics and Thermodynamics [O] . Erik D. Holmstrom, David J. Nesbitt, * -1

机译：对单分子荧光的校正人类端粒酶RNA假结的共振能量转移研究：与温度/尿素有关的折叠动力学和热力学
7. Fluorescence resonance energy transfer study of the global folding of functional DNAs and electrohydrodynamic printing of protein arrays [O] . He Ying 2011

机译：荧光共振能量转移研究功能DNa的全局折叠和蛋白质阵列的电流体动力学印刷

Fluorescence resonance energy transfer dynamics during protein folding: Evidence of multistage folding kinetics

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