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Immunological approaches for HIV therapy.

机译：HIV治疗的免疫学方法。

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The induction of a Th-1 polarized immune response is believed to be advantageous when designing immunologic approaches for HIV therapy. DNA vaccines represent one of the best immunologic strategies capable of inducing such a response. From conception to clinical application it is now possible to rationally design DNA vaccines based on reliable experimental data, thus a systemic approach to the development of new and the enhancement of existing vaccine immunogens is now possible. The addition of adjuvants may also increase immunogenicity and depending on the choice of adjuvant, polarize the immune response. Other important factors in the formulation of a successful vaccine are the selection of administration route, heterologous or homologous prime/boost schedules, and the feasibility of the eventual clinical application. This review will summarize recently developed preventive and therapeutic vaccines, and carefully evaluate the advantages and potential risks for Human Immunodeficiency Virus (HIV) infected patients. Finally, the concept of autovaccination development of our innovative therapeutic antigen presenting cell targeted HIV vaccine. DermaVir is the first topical vaccine, in combination with antiretroviral therapy, to demonstrate immunological and clinical benefits in a relevant animal model (chronically infected rhesus macaques).
机译：当设计用于HIV治疗的免疫学方法时，认为Th-1极化免疫应答的诱导是有利的。 DNA疫苗代表了能够诱导这种反应的最佳免疫策略之一。从概念到临床应用，现在有可能基于可靠的实验数据合理设计DNA疫苗，因此，现在有可能采用系统方法开发新的和增强现有的疫苗免疫原。佐剂的添加也可以增加免疫原性，并且取决于佐剂的选择，极化免疫反应。配制成功疫苗的其他重要因素是给药途径的选择，异源或同源的初免/加强方案，以及最终临床应用的可行性。这篇综述将总结最近开发的预防和治疗疫苗，并仔细评估人类免疫缺陷病毒（HIV）感染患者的优势和潜在风险。最后，我们创新的治疗性抗原呈递细胞靶向HIV疫苗的自动疫苗研制概念。 DermaVir是首款结合抗逆转录病毒疗法的局部疫苗，可在相关动物模型（慢性感染的恒河猴）中证明其免疫学和临床益处。

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