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Pregnancy and inflammatory bowel disease.

机译：妊娠和炎症性肠病。

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PURPOSE OF REVIEW: Inflammatory bowel disease commonly affects women during the childbearing years, and young couples are often concerned about the potential effects of inflammatory bowel disease on fertility, pregnancy, and the fetus. This review will critically consider advances over the past 2 years in our knowledge of the effects of inflammatory bowel disease on fertility and pregnancy outcome and the safety and efficacy of medical therapy in the pregnant woman with inflammatory bowel disease. RECENT FINDINGS: The past several years have witnessed significant additions to our knowledge of the effects of ulcerative colitis and Crohn disease on fetal outcome. In addition, important studies have added to the growing database pointing to the overall safety of medical therapy with aminosalicylates and immunomodulators during pregnancy. Limited new data also suggest that inadvertent exposure to infliximab appears not to be harmful to the fetus. SUMMARY: Women with Crohn disease appear to be at risk for early delivery and low birthweight infants, and women with ulcerative colitis may be at increased risk for giving birth to children with congenital abnormalities. The clinical significance of these results may be diluted, however, by inability to adequately assess the confounding influence of disease activity or drug treatment. Despite lingering concerns, the most recent data support the overall safety of the 5-aminosalicylate drugs as well as azothiaprine/6-mercaptopurine during pregnancy. Despite these advances, the potential complications of inflammatory bowel disease and its therapies during pregnancy continue to require careful discussion with each individual couple before conception.
机译：审查目的：炎症性肠病通常在育龄期影响妇女，而年轻夫妇则经常担心炎症性肠病对生育，怀孕和胎儿的潜在影响。这篇综述将认真考虑过去两年来我们对炎症性肠病对生育能力和妊娠结局的影响以及药物治疗炎症性肠病的安全性和有效性的认识。最近的发现：在过去的几年中，我们对溃疡性结肠炎和克罗恩病对胎儿结局的影响的认识大大增加。此外，重要的研究已添加到不断增长的数据库中，指出在怀孕期间使用氨基水杨酸酯和免疫调节剂进行药物治疗的总体安全性。有限的新数据还表明，英夫利昔单抗的无意暴露似乎对胎儿无害。摘要：患有克罗恩病的妇女似乎有可能早产和低出生体重婴儿的风险，而患有溃疡性结肠炎的妇女生下先天性异常儿童的风险可能更高。但是，由于无法充分评估疾病活动或药物治疗的混杂影响，可能会削弱这些结果的临床意义。尽管存在令人担忧的担忧，但最新数据支持5-氨基水杨酸盐​​药物以及偶氮噻嗪/ 6-巯基嘌呤在怀孕期间的整体安全性。尽管取得了这些进展，但怀孕期间炎症性肠病及其治疗的潜在并发症仍需要在怀孕前与每对夫妇仔细讨论。

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