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首页> 外文期刊>Current opinion in gastroenterology >Update on branched-chain amino acid supplementation in liver diseases.
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Update on branched-chain amino acid supplementation in liver diseases.

机译：肝病中支链氨基酸补充的最新进展。

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PURPOSE OF REVIEW: Branched-chain amino acids (BCAAs) have a peculiar role in whole-body nitrogen metabolism. BCAAs are a substrate for protein synthesis, and have been used to conserve or restore muscle mass in advanced liver disease. In addition, the competitive action of BCAAs on amino acid transport across the blood-brain barrier may improve hepatic encephalopathy. RECENT FINDINGS: The effects of branched-chain amino acids on nutrition and ultimately on prognosis of patients with advanced cirrhosis have been confirmed in a large multicenter, long-term trial. Similarly, BCAA treatment improved the prognosis of patients with hepatocellular carcinoma, treated by chemoembolization. The mechanism for the beneficial effects of BCAA is likely to depend on the stimulating activity of BCAA on hepatocyte growth factor, favoring liver regeneration. SUMMARY: After an experience of 25 years with branched-chain amino acids, new data supports their beneficial effect in liver diseases. Although the number of patients who cannot tolerate dietary proteins in amounts sufficient to meet their increased catabolism is probably low, in this specific setting BCAAs remain the sole treatment of proved efficacy.
机译：审查目的：支链氨基酸（BCAAs）在全身氮代谢中起特殊作用。 BCAA是蛋白质合成的底物，已被用于保存或恢复晚期肝脏疾病中的肌肉质量。此外，BCAA对跨血脑屏障的氨基酸转运的竞争作用可能会改善肝性脑病。最新发现：在一项大型的多中心长期试验中，已经证实了支链氨基酸对营养的影响以及对晚期肝硬化患者的预后的影响。同样，通过化学栓塞治疗，BCAA治疗可改善肝细胞癌患者的预后。 BCAA有益作用的机制可能取决于BCAA对肝细胞生长因子的刺激活性，有利于肝脏再生。简介：在使用支链氨基酸已有25年的经验之后，新数据支持了它们在肝脏疾病中的有益作用。尽管不能忍受足够满足其增加的分解代谢的量的饮食蛋白的患者人数可能很低，但在这种特定情况下，BCAAs仍然是证明疗效的唯一方法。

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