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首页> 外文期刊>The Journal of investigative dermatology. >CXCL5 Facilitates Melanoma Cell-Neutrophil Interaction and Lymph Node Metastasis
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CXCL5 Facilitates Melanoma Cell-Neutrophil Interaction and Lymph Node Metastasis

机译：CXCL5促进黑素瘤细胞 - 中性粒细胞相互作用和淋巴结转移

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摘要

Chemokines influence tumor metastasis by targeting tumor, stromal, and hematopoietic cells. Characterizing the chemokine mRNA expression profile of human primary melanoma samples, we found CXCL5 significantly up-regulated in stage T4 primary melanomas when compared to thin melanomas (T1 stage). To characterize the role of CXCL5 in melanoma progression, we established a metastasizing murine xenograft model using CXCL5-overexpressing human melanoma cells. CXCL5 had no effect on melanoma proliferation in vitro and on primary tumor growth in vivo, but CXCL5-overexpressing tumors recruited high amounts of neutrophils and exhibited significantly increased lymphangiogenesis in our severe combined immune-deficient mouse model. Recruited neutrophils were found in close proximity to or within lymphatic vessels, often in direct contact with melanoma cells. Clinically, CXCL5-overexpressing melanomas had significantly increased lymph node metastases. We were able to translate these findings to human patient samples and found a positive correlation between CXCL5 expression, numbers of neutrophils in stage T4 primary melanoma, and the occurrence of subsequent locoregional metastasis.
机译：趋化因子通过靶向肿瘤，基质和造血细胞来影响肿瘤转移。表征人初级黑色素瘤样品的趋化因子mRNA表达谱，我们发现与薄黑色素瘤（T1阶段）相比，在T4初级黑色素瘤中显着上调CXCl5。为了表征CXCL5在黑色素瘤进展中的作用，我们使用CXCL5过表达人黑素瘤细胞建立了鼠异叶移植模型。 CXCL5对体内体内运动瘤增殖和体内原发性肿瘤生长没有影响，但CXCL5过表达肿瘤募集了大量中性粒细胞，并在我们的严重组合免疫缺陷小鼠模型中表现出显着增加的淋巴管发生。令人携带的嗜中性粒细胞在淋巴管中靠近或淋巴血管内，通常与黑素瘤细胞直接接触。临床上，CXCL5过表达黑色素瘤具有显着增加的淋巴结转移。我们能够将这些发现转化为人类患者样品，并发现CXCL5表达，阶段T4初级黑素瘤中嗜中性粒细胞数的正相关性，以及随后的型局部转移的发生。

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    Soler-Cardona Ana; Forsthuber Agnes; Lipp Katharina; Ebersberger Stefanie; Heinz Magdalena; Schossleitner Klaudia; Buchberger Elisabeth; Groeger Marion; Petzelbauer Peter; Hoeller Christoph; Wagner Erwin; Loewe Robert;

  • 作者单位

    Med Univ Vienna Dept Dermatol Skin &

    Endothelium Res Div Waehringer Guertel 18-20 A-1090 Vienna;

    Med Univ Vienna Dept Dermatol Skin &

    Endothelium Res Div Waehringer Guertel 18-20 A-1090 Vienna;

    Med Univ Vienna Dept Dermatol Skin &

    Endothelium Res Div Waehringer Guertel 18-20 A-1090 Vienna;

    Inst Mol Biol GmbH Mainz Germany;

    Med Univ Vienna Dept Dermatol Skin &

    Endothelium Res Div Waehringer Guertel 18-20 A-1090 Vienna;

    Med Univ Vienna Dept Dermatol Skin &

    Endothelium Res Div Waehringer Guertel 18-20 A-1090 Vienna;

    Med Univ Vienna Dept Surg Vienna Austria;

    Med Univ Vienna Clin Inst Med &

    Chem Lab Diagnost Core Facil Imaging Vienna Austria;

    Med Univ Vienna Dept Dermatol Skin &

    Endothelium Res Div Waehringer Guertel 18-20 A-1090 Vienna;

    Med Univ Vienna Dept Dermatol Div Gen Dermatol &

    Dermatooncol Vienna Austria;

    Ctr Nacl Invest Oncol Genes Dev &

    Dis Grp Madrid Spain;

    Med Univ Vienna Dept Dermatol Skin &

    Endothelium Res Div Waehringer Guertel 18-20 A-1090 Vienna;

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  • 正文语种 eng
  • 中图分类 皮肤病学与性病学;
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