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Cellular and molecular biology of the liver

机译：肝脏的细胞和分子生物学

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Recently, several lines of investigation focused on basic mechanisms governing cellular and molecular aspects of liver biology have intersected at the study of the hepatic stem cell. Despite years of study, the very question of the existence of the hepatic stem cell has yet to be unequivocally established. A second field of investigation into the cellular and molecular aspects of liver biology is aimed at liver-directed gene therapy in which several new vehicles have been devised to mediate gene transfer. Gene therapy is no longer thought of in the limited framework of a means to correct inherited disorders; it is now expanding into new therapeutic applications. A third major area of investigation includes studies of mechanisms that regulate membrane protein traffic necessary to maintain the integrity of differentiated liver cell function. In this review, some of the most recent advances and applications in these three areas are highlighted, and, where appropriate, points of interaction and potential therapeutic importance are emphasized.
机译：最近，在研究肝干细胞的研究中，有几条研究线集中在控制肝生物学的细胞和分子方面的基本机制上。尽管进行了多年的研究，肝干细胞存在的问题尚未得到明确的确定。肝生物学的细胞和分子方面的第二个研究领域是针对肝定向基因治疗，其中已经设计了几种新的媒介物来介导基因转移。在纠正遗传性疾病的手段有限的框架内，不再考虑基因治疗。现在它正在扩展到新的治疗应用中。研究的第三主要领域包括调节维持分化的肝细胞功能完整性所需的膜蛋白运输的机制的研究。在这篇综述中，重点介绍了这三个领域的一些最新进展和应用，并在适当时强调了相互作用的要点和潜在的治疗重要性。

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