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首页> 外文期刊>Current opinion in gastroenterology >The role of vitamin D in normal and pathologic processes in the colon
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The role of vitamin D in normal and pathologic processes in the colon

机译：维生素D在结肠正常和病理过程中的作用

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Vitamin D_3 metabolites and analogues have recently been shown to play an important role in the regulation of a number of important cellular processes, including proliferation, differentiation, and apoptosis, in addition to their established roles in mineral homeostasis. The actions of these secosteroids involve both rapid, nongenomic effects and genomic effects; the latter mediated via the vitamin D receptor and other transcription factors. Their effects have been described in a variety of cell types, including normal and malignant colonocytes. This article summarizes the rapid and genomic actions of vitamin D_3 metabolites and analogues on normal and pathologic processes in the colon, with particular emphasis on the potential of these secosteroids to prevent colon cancer.
机译：维生素D_3代谢物和类似物最近显示出在许多重要的细胞过程（包括增殖，分化和凋亡）的调节中也起着重要作用，除了它们在矿物质体内稳态中已确立的作用外。这些类固醇的作用涉及快速的非基因组效应和基因组效应。后者通过维生素D受体和其他转录因子介导。已经在包括正常和恶性结肠细胞在内的多种细胞类型中描述了它们的作用。本文总结了维生素D_3代谢物和类似物对结肠正常和病理过程的快速和基因组作用，并特别强调了这些类固醇预防结肠癌的潜力。

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