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Receptor biology and signal transduction

机译：受体生物学与信号转导

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This year has witnessed substantial advances in receptor biology and signal transduction that are relevant to the function and regulation of the healthy pancreas and to the pathogenesis and potential therapy of pancreatitis and pancreatic carcinoma. There has been an expansion in the cast of pancreatic regulatory molecules, now including protease-activated receptors, chemokines, and chemokine receptors. There have been new insights into the cellular distribution and signaling initiated at the classic pancreatic receptors. There have also been dramatic advances in insights into the structure of G protein-coupled receptors, with the first solution of a crystal structure of a member of this superfamiiy, and into the molecular basis of ligand binding and activation of these important molecules. This will clearly improve the opportunities for the rational design and refinement of receptor-active drugs. In addition to these fundamental advances, there has been renewed attention to the expression, function, and regulation of receptors and signaling pathways in pancreatic cells present in the setting of pancreatitis and pancreatic carcinoma. It is hoped that this will contribute toward earlier diagnosis, more successful therapy, and new chemopreventive strategies for these illnesses.
机译：今年，在受体生物学和信号转导方面取得了重大进展，这些进展与健康胰腺的功能和调节以及胰腺炎和胰腺癌的发病机理及潜在治疗有关。胰腺调节分子的种类有所增加，现在包括蛋白酶激活受体，趋化因子和趋化因子受体。对于经典的胰脏受体启动的细胞分布和信号传导有了新的见解。关于G蛋白偶联受体的结构，该超家族成员的晶体结构的第一个解决方案以及配体结合和激活这些重要分子的分子基础的见解，也取得了重大进展。这将明显增加合理设计和完善受体活性药物的机会。除了这些基本进展外，人们对胰腺炎和胰腺癌中存在的胰腺细胞中受体和信号通路的表达，功能和调节也有了新的关注。希望这将有助于这些疾病的早期诊断，更成功的治疗和新的化学预防策略。

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