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首页> 外文期刊>Current opinion in gastroenterology >Drug-induced liver injury: a clinical update
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Drug-induced liver injury: a clinical update

机译：药物性肝损伤：临床更新

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Purpose of review To gather new and important data published on idiosyncratic drug-induced liver injury (DILI) over the past 2 years in the peer-reviewed literature. Clinical studies focusing on mechanisms of injury, clinical evaluation and prognosis will be reviewed. Recent findings The most common drugs leading to DILI in the United States are antibiotics, central nervous system agents, herbal/dietary supplements and immunomodulatory agents. Hepatocellular type of DILI is more common in younger patients, whereas cholestatic pattern increases with older age. Certain human leukocyte antigen genotype increases the likelihood of flucloxacillin-induced liver injury. Idiosyncratic DILI was shown to have an important dose-dependency and drugs with extensive hepatic metabolism are associated with higher frequency of DILI. Chronic DILI may occur, but development of clinically important liver injury after severe DILI is rare. A/-acetylcysteine seems to be beneficial for patients with acute liver failure caused by medications or herbal agents.
机译：综述的目的在过去两年的同行评审文献中，收集有关特异药物性肝损伤（DILI）的新的重要数据。将会着重研究针对损伤机制，临床评估和预后的临床研究。最新发现在美国，导致DILI的最常见药物是抗生素，中枢神经系统药物，草药/饮食补充剂和免疫调节剂。肝细胞型DILI在年轻患者中更为常见，而胆汁淤积型则随着年龄的增长而增加。某些人类白细胞抗原基因型增加了氟氯西林诱导的肝损伤的可能性。异质性DILI被证明具有重要的剂量依赖性，具有广泛肝代谢的药物与更高的DILI发生率相关。可能发生慢性DILI，但很少发生严重DILI后临床上重要的肝损伤的发生。 A /-乙酰半胱氨酸似乎对药物或草药引起的急性肝衰竭患者有益。

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