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Update on human Campylobacter jejuni infections

机译：空肠弯曲菌感染的最新情况

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摘要

Purpose of review The present review will update the reader to the clinical, epidemiological and immunologic advances in the field of human campylobacteriosis. Recent findings New advances in human campylobacteriosis include an increased appreciation of the role of Campylobacter jejuni in postinfectious sequelae, a broadened understanding of Campylabacter-associated disease burden and the interplay between host immunity and bacterial factors. Antibiotic management has also become more complex: C. jejuni has undergone a rapid increase in resistance to the fluoroquinolone antibiotics and concurrently, postinfectious irritable bowel syndrome has been associated with a longer duration of untreated infection. In anticipation of new candidate C. jejuni vaccines, progress in understanding human immune responses to infection has been made via human experimental infections. These tightly controlled studies have also increased our understanding of the natural history of campylobacteriosis as well as observations of recrudescent infection following treatment with C. jejuni-sensitive antibiotics. Summary As one of the most common agents of bacterial gastroenteritis and a major health burden for both developing world and industrialized nations, Campylobacter infections remain a high priority for research efforts to improve prevention and management. Priorities for the future include vaccine development, pathogen-specific immunity and identification of risk factors for postinfectious sequelae.
机译：综述的目的本综述将向读者介绍人类弯曲菌病领域的临床，流行病学和免疫学进展。最新发现人类弯曲杆菌病的新进展包括对空肠弯曲菌在感染后后遗症中的作用的认识增加，对弯曲杆菌相关疾病负担以及宿主免疫力和细菌因素之间相互作用的广泛理解。抗生素的管理也变得更加复杂：空肠弯曲杆菌对氟喹诺酮类抗生素的耐药性迅速增加，与此同时，感染后肠易激综合症与未经治疗的感染时间更长有关。预期有新的空肠弯曲杆菌疫苗，通过人类实验性感染已经在了解人类对感染的免疫反应方面取得了进展。这些严格控制的研究也增加了我们对弯曲杆菌自然病史的了解，以及对空肠弯曲杆菌敏感抗生素治疗后复发感染的观察。总结作为细菌性肠胃炎的最常见病原体之一，并且是发展中国家和工业化国家的主要健康负担，弯曲杆菌感染仍然是改善预防和管理研究工作的高度优先事项。未来的优先事项包括疫苗开发，病原体特异性免疫力和确定感染后后遗症的危险因素。

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