• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Current opinion in gastroenterology >Inflammatory bowel disease and colitis: new concepts from the bench and the clinic
【24h】

Inflammatory bowel disease and colitis: new concepts from the bench and the clinic

机译：炎性肠病和结肠炎：板凳和临床的新概念

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Purpose of review The previous 18 months have shown important progress in unravelling the causes of inflammatory bowel disease (IBD) and in improving its management for the patients. Recent findings More genome-wide association studies and meta-analyses of these have been published and have identified more than 100 confirmed genes for IBD, and highlighted a number of novel pathways. Two of the genes, NOD2/CARD15 and the autophagy gene ATG16L1 have recently been linked into one functional pathway of bacterial sensing, invasion and elimination. From the clinical side, the previous year has been dominated mainly by the results of the SONIC study, comparing efficacy and safety of azathioprine, infliximab and the combination of azathioprine and infliximab, in patients with active Crohn's disease, naive to these drugs. International consensus guidelines on infection prevention were released last year by the European Crohn's and Colitis Organisation. Summary The recent findings in IBD include the increasing number of IBD susceptibility genes, the demonstration that N0D2 and ATG16L1 are linked in one functional pathway and the role of IL-33/ST2 in colitis. From the bedside, the novelties have been the results of SONIC and selecting the right patient for intensified treatment with immunomodulators and anti-tumor necrosis factor, and appropriate counselling regarding risk of infections and vaccinations.
机译：回顾的目的在过去的18个月中，在阐明炎症性肠病（IBD）的病因和改善对患者的管理方面已显示出重要的进展。最近的发现已经发表了更多的全基因组关联研究和荟萃分析，并鉴定了100多个IBD确诊基因，并着重介绍了许多新颖的途径。 NOD2 / CARD15和自噬基因ATG16L1这两个基因最近已与细菌感测，侵袭和消除的一个功能途径相关。从临床角度来看，前一年主要由SONIC研究的结果决定，该研究比较了硫唑嘌呤，英夫利昔单抗以及硫唑嘌呤和英夫利昔单抗联合治疗活动性克罗恩病患者的疗效和安全性，而这些药物尚未使用过。欧洲克罗恩氏和结肠炎组织于去年发布了有关预防感染的国际共识准则。总结IBD的最新发现包括IBD易感性基因数量的增加，N0D2和ATG16L1在一个功能途径中相关联以及IL-33 / ST2在结肠炎中的作用的证明。从床头看，新颖性是SONIC的结果，它选择了合适的患者进行免疫调节剂和抗肿瘤坏死因子的强化治疗，并就感染和接种疫苗的风险提供了适当的建议。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号