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首页> 外文期刊>The Journal of Neuroscience: The Official Journal of the Society for Neuroscience >Complex spike activity of purkinje cells in the oculomotor vermis during behavioral adaptation of monkey saccades.
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Complex spike activity of purkinje cells in the oculomotor vermis during behavioral adaptation of monkey saccades.

机译：猴子扫描行为适应期间脓血细胞在猴子扫描期间的复杂尖峰活动。

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摘要

Throughout life, the oculomotor system can correct itself when saccadic eye movements become inaccurate. This adaptation mechanism can be engaged in the laboratory by displacing the target when the saccade toward it is in flight. Forward and backward target displacements cause gradual increases and decreases in saccade amplitude, respectively. Equipped with this paradigm, we asked whether Purkinje cells (P-cells) in the vermis of the oculomotor cerebellum, lobules VIc and VII, changed their complex spike (CS) discharge during the behavioral adaptation of horizontal saccades. We tested the hypothesis that CS activity would change only when a targeting saccade caused an error in eye position relative to the target, i.e., during the error interval between the primary and corrective saccades. We examined only those P-cells whose simple spike activity exhibited either a burst or pause with saccades in several directions. Approximately 80% of such P-cells exhibited an increase in CS activity during the errorinterval when the adaptation paradigm imposed horizontal eye-position errors in one direction and a decrease in activity for errors in the other. As adaptation progressed and errors were reduced, there was no consistent change in the CS activity. These data suggest that the CS activity of P-cells in the oculomotor vermis signals the direction but not the magnitude of eye-position error during saccade adaptation. Our results are consistent with cerebellar learning models that have been proposed to explain adaptation of the vestibulo-ocular reflex so similar mechanisms may also underlie plasticity of this precision voluntary oculomotor behavior.
机译：在整个寿命期间，扫视眼球运动变得不准确时，动力系统可以纠正自己。当朝向它在飞行中时，这种适配机构可以通过使扫视朝向飞行时的目标从事实验室。向前和向后的目标位移分别导致扫描幅度逐渐增加和降低。配备该范例，我们询问紫癜细胞（p细胞）是否在血管肌细胞，叶片VIC和VII的蚓部中，在水平扫描的行为适应期间改变了它们的复杂峰值（CS）放电。我们测试了CS活动的假设才会仅当目标扫视引起对目标的眼位置误差时，即在主要和校正扫描之间的错误间隔期间。我们只检查了那些简单的尖峰活动的P细胞在几个方向上表现出突发或暂停囊。当适应范例在一个方向上施加水平的眼睛位置误差时，大约80％的这种P细胞在误差过程中表现出CS活动的增加，并且在另一个方向上施加水平的眼睛位置误差。随着适应的进展和错误减少，CS活动没有一致的变化。这些数据表明，动声器蚓部在囊间蚓部中的P细胞的CS活性在扫视自适应期间的仰卧位误差的方向表示。我们的结果与大脑学习模型一致，已经提出了解释了前胃眼睛反射的适应，因此类似的机制也可能具有这种精确自愿动力运动行为的可塑性。

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