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首页> 外文期刊>The Journal of Neuroscience: The Official Journal of the Society for Neuroscience >Theta-band phase locking of orbitofrontal neurons during reward expectancy.
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Theta-band phase locking of orbitofrontal neurons during reward expectancy.

机译：在奖励期间胰蛋白酶神经元的Theta带相位锁定。

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The expectancy of a rewarding outcome following actions and cues is coded by a network of brain structures including the orbitofrontal cortex. Thus far, predicted reward was considered to be coded by time-averaged spike rates of neurons. However, besides firing rate, the precise timing of action potentials in relation to ongoing oscillations in local field potentials is thought to be of importance for effective communication between brain areas. We performed multineuron and field potential recordings in orbitofrontal cortex of rats performing olfactory discrimination learning to study the temporal structure of coding predictive of outcome. After associative learning, field potentials were marked by theta oscillations, both in advance and during delivery of reward. Orbitofrontal neurons, especially those coding information about upcoming reward with their firing rate, phase locked to these oscillations in anticipation of reward. When established associations were reversed, phase locking collapsed in the anticipatory task phase, but returned when reward became predictable again after relearning. Behaviorally, the outcome anticipation phase was marked by licking responses, but the frequency of lick responses was dissociated from the strength of theta-band phase locking. The strength of theta-band phase locking by orbitofrontal neurons robustly follows the dynamics of associative learning as measured by behavior and correlates with the rat's current outcome expectancy. Theta-band phase locking may facilitate communication of outcome-related information between reward-related brain areas and offers a novel mechanism for coding value signals during reinforcement learning.
机译：奖励结果遵守行动和提示的期望由包括胰肿大皮质的脑结构网络进行编码。到目前为止，预测奖励被认为是通过时间平均的神经元的尖峰率编码。然而，除了射击率之外，与当地现场电位的持续振荡相关的动作电位的精确时间被认为是脑区域之间有效沟通的重要性。我们在表演嗅觉鉴别学习的大鼠胰腺癌皮质中进行了多阵容和现场潜在记录，以研究编码预测结果的时间结构。在联想学习之后，现场潜力是由Theta振荡的标志，无论是提前还是在交付期间的奖励期间。 Orbitofrontal Neurons，特别是那些编码信息，了关于越来越多的奖励的射击率，阶段锁定在预期奖励中的振荡。当建立的关联被逆转时，在预期的任务阶段倒塌阶段锁定，但是在重新安排后再次奖励再次预测时返回。行为地，通过舔响应标记结果预期阶段，但舔响应的频率是从θ带相位锁定的强度解离。通过胰胰胰蛋白酶神经元锁定的Theta带阶段锁定的强度促使关联学习的动态遵循通过行为测量的关联学习的动态，并与RAT的当前结果期望寿命相关。段带相位锁定可以促进与奖励相关的大脑区域之间的结果相关信息的通信，并在加固学习期间提供用于编码价值信号的新机制。

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