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首页> 外文期刊>The Journal of Neuroscience: The Official Journal of the Society for Neuroscience >Structural dynamics of synapses in vivo correlate with functional changes during experience-dependent plasticity in visual cortex.
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Structural dynamics of synapses in vivo correlate with functional changes during experience-dependent plasticity in visual cortex.

机译：VIVO中突触的结构动力学与视觉皮质经验依赖性可塑性的功能变化相关。

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摘要

The impact of activity on neuronal circuitry is complex, involving both functional and structural changes whose interaction is largely unknown. We have used optical imaging of mouse visual cortex responses and two-photon imaging of superficial layer spines on layer 5 neurons to monitor network function and synaptic structural dynamics in the mouse visual cortex in vivo. Total lack of vision due to dark-rearing from birth dampens visual responses and shifts spine dynamics and morphologies toward an immature state. The effects of vision after dark rearing are strongly dependent on the timing of exposure: over a period of days, functional and structural changes are temporally related such that light stabilizes spines while increasing visually driven activity. The effects of long-term light exposure can be partially mimicked by experimentally enhancing inhibitory signaling in the darkness. Brief light exposure, however, results in a rapid, transient, NMDA-dependent increase of cortical responses, accompanied by increased dynamics of dendritic spines. These findings indicate that visual experience induces rapid reorganization of cortical circuitry followed by a period of stabilization, and demonstrate a close relationship between dynamic changes at single synapses and cortical network function.
机译：活动对神经元电路的影响是复杂的，涉及功能性和结构变化，其相互作用在很大程度上是未知的。我们已经使用过鼠标视觉皮质响应的光学成像和在第5层神经元上的浅表层刺的两光子成像，以监测体内小鼠视觉皮层中的网络功能和突触结构动态。由于从出生的暗训中造成暗致抑制而缺乏视力，并将脊柱动态和形态移向未成熟状态。暗饲养后的视觉效果强烈依赖于暴露的时机：在一段时间内，功能性和结构变化在时间上有关，使得光稳定刺刺，同时增加视觉驱动的活性。通过在黑暗中通过实验增强抑制信号传导可以部分地模仿长期曝光的效果。然而，短暂的曝光导致皮质反应的快速，瞬态，NMDA依赖性增加，伴随着树突刺的增加的动态。这些发现表明，视觉经验引起皮质电路的快速重组，然后稳定，并在单个突触和皮质网络功能之间展示动态变化之间的密切关系。

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