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首页> 外文期刊>The Journal of Neuroscience: The Official Journal of the Society for Neuroscience >Proximodistal Structure of Theta Coordination in the Dorsal Hippocampus of Epileptic Rats
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Proximodistal Structure of Theta Coordination in the Dorsal Hippocampus of Epileptic Rats

机译：癫痫大鼠背海马中θ的替代性结构

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Coherent neuronal activity in the hippocampal-entorhinal circuit is a critical mechanism for episodic memory function, which is typically impaired in temporal lobe epilepsy. To better understand how this mechanism is implemented and degraded in this condition, we used normal and epileptic rats to examine theta activity accompanying active exploration. Assisted by multisite recordings of local field potentials (LFPs) and layer-specific profiling of input pathways, we provide detailed quantification of the proximodistal coherence of theta activity in the dorsal hippocampus of these animals. Normal rats showed stronger coordination between the temporoammonic and perforant entorhinal inputs (measured from lamina-specific current source density signals) at proximal locations, i.e., closer to CA3; while epileptic rats exhibited stronger interactions at distal locations, i.e., closer to subiculum. This opposing trend in epileptic rats was associated with the reorganization of the temporoammonic and perforant pathways that accompany hippocampal sclerosis, the pathological hallmark of this disease. In addition to this connectivity constraint, we discovered that the appropriate timing between entorhinal inputs arriving over several theta cycles at the proximal and distal ends of the dorsal hippocampus was impaired in epileptic rats. Computational reconstruction of LFP signals predicted that restoring timing variability has a major impact on repairing theta coherence. This manipulation, when tested pharmacologically via systemic administration of group III mGluR antagonists, successfully re-established theta coordination of LFPs in epileptic rats. Thus, proximodistal organization of entorhinal inputs is instrumental in temporal lobe physiology and a candidate mechanism to study cognitive comorbidities of temporal lobe epilepsy.
机译：海马 - 熵电路中的相干神经元活性是颞下记忆功能的关键机制，其通常在颞叶癫痫中受损。为了更好地了解这种机制在这种情况下如何实现和降解，我们使用正常和癫痫大鼠来检查活动探索的θ活性。通过局部现场电位（LFP）和输入途径的层特异性分析的多路录制，我们提供了这些动物背部海马中θ活性的详细量化。正常的大鼠在近端位置处的颞膜子和穿孔射流输入（从层叠电流源密度信号测量）之间的较强的协调，即更接近CA3;虽然癫痫大鼠在远端位置表现出更强的相互作用，即更接近次要。癫痫大鼠的这种反对趋势与伴随海马硬化的颞膜和穿孔途径的重组有关，该疾病的病理标志。除了这种连接约束之外，我们发现在癫痫大鼠的近端和远端处于近侧和远端到达几个循环的基因输入之间的适当时序在癫痫大鼠中受到损害。 LFP信号的计算重建预测，恢复定时变异性对修复Theta连贯性具有重要影响。这种操作，当通过系统性施用III族MGLUR拮抗剂进行药理学施用时，在癫痫大鼠中成功地重新建立了LFP的θ。因此，临床投入的替代主义组织是颞叶生理学的仪器，以及研究颞叶癫痫的认知融化性的候选机制。

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