...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Current opinion in gastroenterology >Rotavirus and biliary atresia: Can causation be proven?
【24h】

Rotavirus and biliary atresia: Can causation be proven?

机译：轮状病毒和胆道闭锁：是否可以证明病因？

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Purpose of review: New knowledge on rotavirus infection in children and well established mouse models has renewed interest in whether rotavirus could cause biliary atresia, an idiopathic, obliterative infantile disease of bile ducts that is the primary indication for liver transplant in children. Recent findings: Studies in the rotavirus mouse model of biliary atresia indicate that infection of biliary epithelium is an inaugural event leading to biliary inflammation and obstruction, which is preceded by systemic spread of rotavirus, which also occurs during human rotavirus enteric infections. Viral factors, including rotavirus gene 4, are important for biliary infection and biliary atresia in mice. Specific host factors related to inflammatory processes (natural killer and T cells, interferon) are also critical, and a paucity of regulatory T cells in neonates may play a key role in pathogenesis in experimental biliary atresia. Rotavirus vaccination has substantially decreased rotavirus diarrheal disease worldwide and might enable demonstration of a cause-effect relationship between rotavirus infection and biliary atresia in humans. Summary: Rotavirus can be detected in the serum of mice and children and causes biliary atresia in neonatal mice. Approaches to re-examine whether rotavirus causes biliary atresia in children are discussed based on concepts from the mouse model of biliary atresia and rotavirus vaccination programs.
机译：审查目的：关于儿童轮状病毒感染的新知识和完善的小鼠模型，引起了人们对于轮状病毒是否会引起胆道闭锁的兴趣，这是一种特发性，闭塞性胆管疾病，是儿童肝移植的主要指征。最近的发现：对轮状病毒闭锁的轮状病毒小鼠模型的研究表明，胆道上皮的感染是导致胆道发炎和阻塞的首发事件，在此之前轮状病毒的系统性传播，这也发生在人轮状病毒肠感染中。包括轮状病毒基因4在内的病毒因子对于小鼠胆道感染和胆道闭锁很重要。与炎症过程相关的特定宿主因子（自然杀伤力和T细胞，干扰素）也很关键，新生儿中缺乏调节性T细胞可能在实验性胆道闭锁的发病机理中起关键作用。轮状病毒疫苗接种已在全世界范围内大大减少了轮状病毒腹泻病，并可能证明轮状病毒感染与人类胆道闭锁之间存在因果关系。摘要：轮状病毒可以在小鼠和儿童的血清中检测到，并引起新生小鼠的胆道闭锁。基于小鼠的胆道闭锁模型和轮状病毒疫苗接种计划的概念，讨论了重新检查轮状病毒是否导致儿童胆道闭锁的方法。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号