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首页> 外文期刊>The Journal of Neuroscience: The Official Journal of the Society for Neuroscience >Distinct Laterality in Forelimb- Movement Representations of Rat Primary and Secondary Motor Cortical Neurons with Intratelencephalic and Pyramidal Tract Projections
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Distinct Laterality in Forelimb- Movement Representations of Rat Primary and Secondary Motor Cortical Neurons with Intratelencephalic and Pyramidal Tract Projections

机译：具有脑内脑子和金字塔平坦投影的大鼠初级和二次运动皮质神经元的前肢运动表示中的独特横向性

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摘要

Two distinct motor areas, the primary and secondary motor cortices (M1 and M2), play crucial roles in voluntary movement in rodents. The aim of this study was to characterize the laterality in motor cortical representations of right and left forelimb movements. To achieve this goal, we developed a novel behavioral task, the Right-Left Pedal task, in which a head-restrained male rat manipulates a right or left pedal with the corresponding forelimb. This task enabled us to monitor independent movements of both forelimbs with high spatiotemporal resolution. We observed phasic movement-related neuronal activity (Go-type) and tonic hold-related activity (Hold-type) in isolated unilateral movements. In both M1 and M2, Go-type neurons exhibited bias toward contralateral preference, whereas Hold-type neurons exhibited no bias. The contralateral bias was weaker in M2 than M1. Moreover, we differentiated between intratelencephalic (IT) and pyramidal tract (PT) neurons using optogenetically evoked spike collision in rats expressing channelrhodopsin-2. Even in identified PT and IT neurons, Hold-type neurons exhibited no lateral bias. Go-type PT neurons exhibited bias toward contralateral preference, whereas IT neurons exhibited no bias. Our findings suggest a different laterality of movement representations of M1 and M2, in each of which IT neurons are involved in cooperation of bilateral movements, whereas PT neurons control contralateral movements.
机译：两个不同的电动机区域，初级和次级电机皮质（M1和M2），在啮齿动物的自愿运动中起着至关重要的作用。本研究的目的是在右侧和左前肢运动的运动皮质陈述中表征横向性。为了实现这一目标，我们开发了一种新的行为任务，左左踏板任务，其中一个头枕的雄性大鼠操纵右侧或左踏板与相应的前肢。此任务使我们能够监控具有高时空分辨率的前肢的独立运动。我们观察到相平性运动相关的神经元活动（Go-Type）和补品持有相关活动（GoSt-Type）在孤立的单边运动中。在M1和M2两者中，Go型神经元表现出对侧偏好的偏差，而保持型神经元没有偏差。对侧偏差在M2中较弱而不是M1。此外，我们使用在表达渠道流学-2的大鼠中使用致敏诱发的尖刺碰撞来区分脑内脑（IT）和金字塔型道（Pt）神经元。即使在鉴定的PT和IT神经元中，保持型神经元也没有横向偏压。 Go-型Pt神经元表现出偏向对侧偏好，而IT神经元没有偏见。我们的研究结果表明了M1和M2的各种运动表示的不同之处，其中IT神经元参与双边运动的合作，而Pt神经元控制对侧运动。

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