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首页> 外文期刊>Current opinion in hematology >Evolving concepts on the microenvironmental niche for hematopoietic stem cells.
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Evolving concepts on the microenvironmental niche for hematopoietic stem cells.

机译：造血干细胞微环境生态位的概念不断发展。

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PURPOSE OF REVIEW: The hematopoietic stem cell niche is critical for the maintenance and proliferation of hematopoietic stem cells and, as such, is not only essential for steady-state hematopoiesis but may also be relevant to hematologic disease. The present review discusses recent advances in the understanding of interactions within the niche, its potential role in disease pathogenesis and models of its use as a therapeutic target. RECENT FINDINGS: Recent studies have continued to provide important insights into the cellular and molecular components constituting the hematopoietic stem cell niche. Niche interactions have been shown to be involved in the pathogenesis of hematologic disease in animal models. Molecular components of the niche involved in these interactions have been identified, and proof of principle that their manipulation can result in therapeutic benefit is available. Finally, pharmacologic manipulation of the niche is now being tested in stem cell-based therapies. SUMMARY: Increasing insights into the molecular architecture of the hematopoietic stem cell niche have led to the exploitation of the niche as a target in stem cell therapies and offer the prospect of niche-targeted therapy as a new treatment modality in hematologic disease.
机译：审查的目的：造血干细胞的利基对于维持和增殖造血干细胞至关重要，因此，不仅对稳态造血功能至关重要，而且可能与血液系统疾病有关。本综述讨论了在生态位内的相互作用的理解，其在疾病发病机理中的潜在作用及其用作治疗靶标的模型的最新进展。最近的发现：最近的研究继续为构成造血干细胞生态位的细胞和分子成分提供重要见解。生态位相互作用已被证明与动物模型中血液系统疾病的发病机理有关。已经确定了与这些相互作用有关的小生境的分子成分，并且有原理证明它们的操纵可导致治疗益处。最后，目前正在基于干细胞的疗法中测试利基的药理处理。简介：对造血干细胞生态位的分子结构的越来越多的了解已导致将生态位开发为干细胞疗法的靶标，并提供了以生态位为靶标的治疗方法作为血液病新疗法的前景。

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