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首页> 外文期刊>The Journal of pediatrics >Trajectories of Body Mass Index from Childhood to Young Adulthood among Patients with Type 1 Diabetes—A Longitudinal Group-Based Modeling Approach Based on the DPV Registry
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Trajectories of Body Mass Index from Childhood to Young Adulthood among Patients with Type 1 Diabetes—A Longitudinal Group-Based Modeling Approach Based on the DPV Registry

机译：1型糖尿病患者童年对幼年的体重指数的轨迹 - 一种基于DPV注册管理机构的纵向基于群体的建模方法

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摘要

ObjectiveTo identify distinct longitudinal patterns of body mass index (BMI) z score in type 1 diabetes from childhood to young adulthood and secondly to determine sex differences as well as associated clinical covariates. Study designA total of 5665 patients with type 1 diabetes (51% male) with follow-up from 8 to 20 years of age from the multicenter diabetes prospective registry DPV were studied (baseline diabetes duration ≥1 years, BMI z score aggregated per year of life). Latent class growth modeling (SAS: PROC TRAJ) was applied to analyze BMI z score over time. ResultsSix distinct BMI z score trajectories were identified (group 1: 7% of patients, group 2: 22%, group 3: 20%, group 4: 16%, group 5: 25%, and group 6: 10%). Group 1, 2, 5, and 6 had an almost stable BMI z score, either in the low, near-normal, high stable, or chronic overweight range. Group 3 (60% girls) increased their BMI during puberty, whereas group 4 (65% boys) had a BMI decrease. Similar patterns were observed for girls only, whereas boys followed nearly stable trajectories without fluctuation over time. Between the near-normal and the other groups, significant differences (P?
机译：ObjectiveTo鉴定儿童1型糖尿病的体重指数（BMI）Z得分的不同纵向模式，其特征在于确定性差异以及相关的临床协变量。研究Designa共有5665名患有1型糖尿病患者（51％男性），从多中心糖尿病前瞻性注册表DPV进行后续到8至20岁以下（基线糖尿病持续时间≥1年，每年汇总BMI Z分数生活）。应用潜在类生长建模（SAS：Proc Traj）应用于随着时间的推移分析BMI Z分数。结果鉴定了不同的BMI Z评分轨迹（第1组：7％的患者，第2组：22％，第3组，第4组，第4组，第5组：25％和第6组第6项）。第1,2,5和6组具有几乎稳定的BMI Z分数，无论是低，近常，高稳定，还是慢性超重范围。第3组（60％的女孩）在青春期期间增加了他们的BMI，而第4组（65％的男孩）有BMI减少。仅针对女孩观察到类似的模式，而男孩遵循几乎稳定的轨迹而不会随着时间的流逝波动而不会波动。在接近正常和其他群体之间，性别比例（p？<β.05）的显着差异，迁移背景，心理健康，高度z得分，糖化血红蛋白A1c，糖尿病治疗，血脂血症，高血压和吸烟。结论青年与1型糖尿病，BMI Z评分轨迹的巨大异质性存在，突出了个性化性别特定干预计划对受不利BMI发展的危险受试者的重要性。

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  • 来源
    《The Journal of pediatrics》 |2018年第2018期|共12页
  • 作者

    Nicole Prinz; Anke Schwandt; Marianne Becker; Christian Denzer; Monika Flury; Maria Fritsch; Angela Galler; Andreas Lemmer; Matthias Papsch; Thomas Reinehr; Joachim Rosenbauer; Reinhard W. Holl;

  • 作者单位

    Institute of Epidemiology and Medical Biometry Central Institute for Biomedical Technology;

    Institute of Epidemiology and Medical Biometry Central Institute for Biomedical Technology;

    Department of Pediatrics Diabetes &

    Endocrinology Care Clinique Pédiatrique Centre Hospitalier;

    Department of Pediatrics and Adolescent Medicine Division of Pediatric Endocrinology and Diabetes;

    Department of Pediatrics and Adolescent Medicine Division of Pediatric Endocrinology and Diabetes;

    Department of Pediatrics and Adolescent Medicine Medical University of Vienna;

    Charité—Universit?tsmedizin Berlin corporate member of Freie Universit?t Berlin Humboldt;

    Department of Pediatrics and Adolescent Medicine Helios Clinical Center;

    Department of Pediatrics and Adolescent Medicine Marienhospital GmbH;

    Department of Pediatric Endocrinology Diabetes and Nutrition Medicine Hospital for Children and;

    German Center for Diabetes Research (DZD);

    Institute of Epidemiology and Medical Biometry Central Institute for Biomedical Technology;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 儿科学;
  • 关键词

    BMI z score; developmental curves; diabetes; puberty; latent class growth modeling;

    机译：BMI Z得分;发育曲线;糖尿病;青春期;潜在阶级增长建模;

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