Photophysics of a Ruthenium Complex with a pi-Extended Dipyridophenazine Ligand for DNA Quadruplex Labeling

Schindler Julian; Traber Philipp; Zedler Linda; Zhang Ying; Lefebvre Jean-Francois; Kupfer Stephan; Graefe Stefanie; Demeunynck Martine; Chavarot-Kerlidou Murielle; Dietzek Benjamin

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Photophysics of a Ruthenium Complex with a pi-Extended Dipyridophenazine Ligand for DNA Quadruplex Labeling

机译：具有Pi延伸双吡啶噻吩配体的钌配合物的光学药物，用于DNA Quadreplyply标记

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The light-switch mechanism of the complex [Ru(bpy)(2)(Br-dpqp)](PF6)(2) (1, bpy = 2,2'-bipyridine, Br-dpqp = 12-bromo-14-ethoxydipyrido[3,2-a:2',3'-c]quinolino[3,2-h]phenazine), i.e., a light-up probe for the selective labeling of Gquadruplexes, is investigated by time-resolved transient absorption and emission spectroscopy. We show that, in contrast to the prototypical light-switch complex [Ru(bpy)(2)(dppz)](PF6)(2) (2, dppz = dipyrido[3,2-a:2',3'-c]phenazine), a (3)pi pi* state localized on the pi-extended ligand is the state determining the excited-state properties in both protic and aprotic environments. In aprotic environments, emission originates from a bright (MLCTphen)-M-3 state, which is thermally accessible from the (3)pi pi* state at ambient temperature. In the presence of water, i.e., in environments resembling in cellulo situations, the thermally accessible (MLCT)-M-3 state is altered and becomes close in energy to the (3)pi pi* state, which induces a rapid excited-state deactivation of the (3)pi pi* state and a comparably weak emission.

机译：复合物[Ru（BPY）（2）（2）（BR-DPQP）]（PF6）（2）（1，Bpy = 2,2'-Biphyridine，BR-DPQP = 12- Bromo-14-的光开关机制乙氧基二吡啶[3,2-A：2'，3'-C]喹啉[3,2-H]吩嗪），即通过时间分辨的瞬态吸收研究了Gquadruperses的选择性标记的光探针发射光谱。我们表明，与原型光开关复合物相比，[ru（bpy）（2）（dppz）]（pf6）（2）（2，dppz = dipyrido [3,2-a：2'，3'- C] Phazazine），在PI延伸配体上定位的（3）PI PI *状态是确定质子和非质子环境中的激发态特性的状态。在非质子环境中，发射源自明亮（MLCTHEN）-M-3状态，其在环境温度下从（3）PI PI *状态可热处理。在水的存在下，即在类似于纤维素情况的环境中，可以改变热可接近的（MLCT）-M-3状态，并在能量上变为（3）PI PI *状态，这引起快速兴奋状态失活（3）PI PI *状态和相对弱发射。

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《The journal of physical chemistry, A. Molecules, spectroscopy, kinetics, environment, & general theory》 |2018年第32期|共12页
作者
Schindler Julian; Traber Philipp; Zedler Linda; Zhang Ying; Lefebvre Jean-Francois; Kupfer Stephan; Graefe Stefanie; Demeunynck Martine; Chavarot-Kerlidou Murielle; Dietzek Benjamin;
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Friedrich Schiller Univ Jena Inst Phys Chem Helmholtzweg 4 D-07743 Jena Germany;

Friedrich Schiller Univ Jena Inst Phys Chem Helmholtzweg 4 D-07743 Jena Germany;

Leibniz Inst Photon Technol Jena IPHT Dept Funct Interfaces Albert Einstein Str 9 D-07745 Jena Germany;

Friedrich Schiller Univ Jena Inst Phys Chem Helmholtzweg 4 D-07743 Jena Germany;

Univ Grenoble Alpes CNRS DPM F-38000 Grenoble France;

Friedrich Schiller Univ Jena Inst Phys Chem Helmholtzweg 4 D-07743 Jena Germany;

Friedrich Schiller Univ Jena Inst Phys Chem Helmholtzweg 4 D-07743 Jena Germany;

Univ Grenoble Alpes CNRS DPM F-38000 Grenoble France;

Univ Grenoble Alpes CNRS CEA Lab Chim &

Biol Metaux F-38000 Grenoble France;

Friedrich Schiller Univ Jena Inst Phys Chem Helmholtzweg 4 D-07743 Jena Germany;

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正文语种 eng
中图分类物理化学（理论化学）、化学物理学;
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专利

1. Photophysics of a Ruthenium Complex with a pi-Extended Dipyridophenazine Ligand for DNA Quadruplex Labeling [J] . Schindler Julian, Traber Philipp, Zedler Linda, The journal of physical chemistry, A. Molecules, spectroscopy, kinetics, environment, & general theory . 2018,第32期

机译：具有Pi延伸双吡啶噻吩配体的钌配合物的光学药物，用于DNA Quadreplyply标记
2. Platinum(ll) Complexes with Dipyridophenazine Ligands as Human Telomerase Inhibitors and Luminescent Probes for G-Quadruplex DNA [J] . Dik-Lung Ma, Chi-Ming Che, Siu-Cheong Yan Journal of the American Chemical Society . 2009,第8期

机译：铂（II）配合物与双吡啶吩嗪配体作为人类端粒酶抑制剂和G-四联体DNA的发光探针。
3. An 111In-labelled bis-ruthenium(ii) dipyridophenazine theranostic complex: mismatch DNA binding and selective radiotoxicity towards MMR-deficient cancer cells [J] . Martin R. Gill, Michael G. Walker, Sarah Able, Chemical science . 2020,第33期

机译：111英寸标记的双钌（II）双倍吡噻吩antanostic复合物：与MMR缺陷型癌细胞的失配DNA结合和选择性辐射毒性
4. Orientation of ruthenium dipyridophenazine complexes In liposome membranes sensitively controlled by ligand substituents [C] . Malin Ardhammar, Per Lincoln, Bengt Norden European Colloid and Interface Society . 2004

机译：通过配体取代基敏感地控制的脂质体膜中钌双倍吡噻吩络合物的取向
5. Photo-driven one and two-electron processes of tetraazatetrapyridopentacene and substituted dipyridophenazine ligands in the presence or absence of zinc and ruthenium complexation. [D] . Aslan, Joseph M. 2012

机译：在有或没有锌和钌络合的情况下，四氮杂叠氮杂环戊并烯和取代的二吡啶并吩嗪配体的光驱动一电子和二电子过程。
6. An 111In-labelled bis-ruthenium(ii) dipyridophenazine theranostic complex: mismatch DNA binding and selective radiotoxicity towards MMR-deficient cancer cells [O] . Martin R. Gill, Michael G. Walker, Sarah Able, 2020

机译：111英寸标记的双钌（II）双倍吡噻吩antanostic复合物：与MMR缺陷型癌细胞的失配DNA结合和选择性辐射毒性
7. Photophysics of Ruthenium(II) Complexes with Thiazole Extended Dipyridophenazine Ligands [O] . -1

机译：钌（II）复合物用噻唑延伸脱吡吡吡啶噻吩配体的光药
8. Nitroxide-Labeled Ru(II)-Polypyridyl Complexes as EPR Probes to Study OrganizedSystems. 2. Combined Photophysical and EPR Investigations of B-DNA [R] . Ottaviani, M. F., Ghatlia, N. D., Bossmann, S. H., 1992

机译：氮氧化物标记的Ru（II） - 多聚吡啶配合物作为EpR探针研究有机体系。 2. B-DNa的光物理和EpR联合研究

Photophysics of a Ruthenium Complex with a pi-Extended Dipyridophenazine Ligand for DNA Quadruplex Labeling

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