• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Current Surgery >Intestinal fatty acid binding protein (I-FABP) for the detection of strangulated mechanical small bowel obstruction.
【24h】

Intestinal fatty acid binding protein (I-FABP) for the detection of strangulated mechanical small bowel obstruction.

机译：肠脂肪酸结合蛋白（I-FABP）用于检测绞窄的机械性小肠梗阻。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

OBJECTIVE: Intestinal fatty acid binding protein (I-FABP), a protein released by necrotic enterocytes, is a useful marker for the detection of ischemia from mechanical small bowel obstruction. DESIGN: Validation cohort. SETTING: Academic medical center. PARTICIPANTS: Cohort of 21 patients admitted with a clinical diagnosis of mechanical small bowel obstruction. Plasma and urine samples were collected from patients upon hospital admission and again immediately before laparotomy if surgical intervention was delayed. RESULTS: Plasma and urine I-FABP levels (pg/ml by enzyme-linked immunosorbent assay) in patients found to have small bowel necrosis at the time of laparotomy were compared with those without significant ischemia upon laparotomy and those that did not require laparotomy and, by default, did not have small bowel ischemia. A positive test was defined as 1000-pg/ml I-FABP in urine and 100-pg/ml I-FABP in plasma. Small bowel necrosis was confirmed in 3 of 21 enrolled patients. Urine I-FABP levels were positive in 3 of 3 patients with necrosis and 3 of 18 patients without necrosis (sensitivity 100%, specificity 83%, PPV 50%, NPV 100%). Plasma I-FABP levels were positive in 3 of 3 patients with necrosis and 4 of 18 patients without necrosis (sensitivity 100%, specificity 78%, PPV 43%, NPV 100%). CONCLUSIONS: I-FABP is a sensitive marker for ischemia in mechanical small bowel obstruction. Additional work should be done to validate I-FABP in a variety of clinical settings and to develop a rapid I-FABP laboratory assay.
机译：目的：肠道脂肪酸结合蛋白（I-FABP）是一种由坏死性肠细胞释放的蛋白，是检测机械性小肠梗阻缺血的有用标志物。设计：验证队列。地点：学术医学中心。研究对象：21例临床诊断为机械性小肠梗阻的患者。入院时和开腹手术前（如果延迟手术干预）再次从患者中收集血浆和尿液样本。结果：将在剖腹手术时发现小肠坏死的患者的血浆和尿液I-FABP水平（通过酶联免疫吸附法测定的pg / ml）与剖腹手术后无明显局部缺血的患者以及不需要剖腹手术的患者进行比较。 ，默认情况下没有小肠缺血。阳性测试定义为尿液中1000-pg / ml I-FABP和血浆中100-pg / ml I-FABP。在21名入组患者中，有3例证实小肠坏死。 3名坏死患者中的3名和18名无坏死患者中的3名尿I-FABP水平为阳性（敏感性100％，特异性83％，PPV 50％，NPV 100％）。 3例坏死患者中的3例和18例无坏死患者中的4例血浆I-FABP水平为阳性（敏感性100％，特异性78％，PPV 43％，NPV 100％）。结论：I-FABP是机械性小肠梗阻缺血的敏感标志物。应该做更多的工作来在各种临床环境中验证I-FABP并发展出快速的I-FABP实验室检测方法。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号