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首页> 外文期刊>Current Eye Research >Do non-steroidal anti-inflammatory drugs delay posterior capsule opacification after phacoemulsification in children? A randomized, prospective controlled trial
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Do non-steroidal anti-inflammatory drugs delay posterior capsule opacification after phacoemulsification in children? A randomized, prospective controlled trial

机译：非类固醇消炎药是否会延迟儿童超声乳化术后后囊混浊？一项随机，前瞻性对照试验

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Purpose: To evaluate the efficacy of topical ketorolac for the prevention of posterior capsule opacification (PCO) in pediatric cataract surgery. Materials and methods: The eyes were prospectively and randomly assigned to receive postoperative 3-month topical ketorolac 0.5% drops with intact posterior capsule (group 1) or primary posterior capsulotomy combined with anterior vitrectomy (group 2). All children had uneventful corneal small-incision phacoemulsification with a primary implantation of a foldable acrylic posterior chamber intraocular lens (IOL). The frequency and timing of severe PCO was evaluated for each group and documented by slit-lamp examination and photography. Results: A total of 38 eyes of 27 children (15 girls, 12 boys) were included in the study. Among them 16 children had unilateral and 11 had bilateral surgery. All cataracts were developmental cases diagnosed between 1 and 7 years of age. There were 20 eyes in group 1 and 18 eyes in group 2. Mean pediatric age at surgery was 38.1 months (1272 months) in group 1 and 34.2 months in group 2 children (1278 months) (p>0.05). Overall mean follow up was 26.3 months (648 months). Clinically significant PCO that finally needed neodymium:YAG laser application developed in four eyes (20.0%) in group 1 and in two eyes (11.1%) in group 2, and the difference was not statistically significant (chi-square test, p >0.05). Conclusions: Long-term postoperative use of topical ketorolac drops with the preservation of posterior capsule was found to be effective for the prevention of PCO in pediatric cataract surgery, at least during the period of this study.
机译：目的：评估局部酮咯酸在小儿白内障手术中预防后囊混浊（PCO）的疗效。材料和方法：前瞻性和随机分配眼睛，接受术后3个月局部用0.5％酮咯酸滴加完整的后囊（组1）或原发后囊切开联合玻璃体前切除术（组2）。所有儿童均进行了可折叠的角膜小切口超声乳化术，并初步植入了可折叠的丙烯酸后房型人工晶状体（IOL）。评估每组严重PCO的频率和时间，并通过裂隙灯检查和摄影记录。结果：共纳入27名儿童的38眼（15名女孩，12名男孩）。其中16例患儿为单侧，11例患儿为双侧。所有的白内障都是在1至7岁之间被诊断为发育性病例。第1组有20只眼，第2组有18只眼。第1组的平均儿科手术年龄为38.1个月（1272个月），第2组的儿童平均手术年龄为34.2个月（1278个月）（p> 0.05）。总体平均随访时间为26.3个月（648个月）。在第1组中有四只眼（20.0％）在第二组中有两只眼（11.1％）出现了最终需要钕：YAG激光应用的临床上显着的PCO，差异无统计学意义（卡方检验，p> 0.05 ）。结论：至少在本研究期间，长期术后局部使用酮咯酸滴眼液并保留后囊可有效预防小儿白内障手术中的PCO。

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