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首页> 外文期刊>Current Eye Research >Spontaneous high myopia in one eye will affect the development of form deprivation myopia in the fellow eye.
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Spontaneous high myopia in one eye will affect the development of form deprivation myopia in the fellow eye.

机译：一只眼睛的自发性高度近视会影响另一只眼睛的形式剥夺性近视的发展。

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PURPOSE: Whether there is an interaction between eyes of individual subjects in refractive development is an important issue to guide experimental designs and help understand mechanisms involved in development of refractive errors. This study investigated whether spontaneous high myopia in one eye will affect refractive development of the fellow eye treated with form deprivation. METHODS: Thirty-four guinea pigs were divided into four groups: MD (monocularly form-deprived animals with a pre-treatment anisometropia /= 10D, n = 9), normal control (non-form deprivation in animals with a pre-treatment anisometropia /= 10D, n = 9). All eyes in different groups underwent biometric measurements on days 0, 12, 24, and 36 of the experiment. RESULTS: High myopia in one eye reduced form deprivation myopia in the fellow treated eye. The change in refraction from 0 to 36 days in the deprived eyes was -3.07D for the MD group, but -1.22D for the anisometropic MD group (-3.07D vs. -1.22D: p = 0.009, independent sample t-test). The amount of vitreous chamber lengthening over the same period in the deprived eyes was 0.19 mm for the MD group, but 0.12 mm for the anisometropic MD group (0.19 mm vs. 0.12 mm: p = 0.038, independent sample t-test). Myopic development in the anisometropic animals is mainly inhibited within the first 12 days compared to normal MD animals. CONCLUSIONS: These results indicate that an interaction in refractive development may exist temporarily between two eyes of a highly anisometropic animal if the visual environment has been changed.
机译：目的：屈光发育过程中个体受试者的眼睛之间是否存在相互作用，是指导实验设计并帮助理解屈光不正发展所涉及的机制的重要问题。这项研究调查了一只眼睛的自发性高度近视是否会影响接受晶状体剥夺治疗的另一只眼睛的屈光发育。方法：将34只豚鼠分为四组：MD（患有单眼晶状体剥夺的动物，其预处理为屈光参差 / = 10D，n = 9），正常对照（患有屈光参差的动物 / = 10D，n = 9）。在实验的第0、12、24和36天，对不同组的所有眼睛进行了生物特征测量。结果：一只眼睛的高度近视减少了另一只接受治疗的眼睛的剥夺性近视。剥夺性眼从0到36天的屈光度变化，MD组为-3.07D，而屈光参差性MD组为-1.22D（-3.07D vs. -1.22D：p = 0.009，独立样本t检验）。剥夺的眼睛在同一时期的玻璃体腔延长量对于MD组为0.19 mm，但对于屈光参差的MD组为0.12 mm（0.19 mm对0.12 mm：p = 0.038，独立样本t检验）。与正常MD动物相比，屈光参差动物的近视发展主要在头12天内受到抑制。结论：这些结果表明，如果改变了视觉环境，高度屈光参差的动物的两只眼睛之间可能暂时存在屈光发育的相互作用。

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