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首页> 外文期刊>The journal of physical chemistry, B. Condensed matter, materials, surfaces, interfaces & biophysical >Hydrophobic Nanoparticles Modify the Thermal Release Behavior of Liposomes
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Hydrophobic Nanoparticles Modify the Thermal Release Behavior of Liposomes

机译：疏水性纳米粒子改变脂质体的热释放行为

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摘要

Understanding the effect of embedded nanoparticles on the characteristics and behavior of lipid bilayers is critical to the development of lipid-nanoparticle assemblies (LNAs) for biomedical applications. In this work we investigate the effect of hydrophobic nanoparticle size and concentration on liposomal thermal release behavior. Decorated LNAs (D-LNAs) were formed by embedding 2 nm (GNP2) and 4 nm (GNP4) dodecanethiol-capped gold nanoparticles into DPPC liposomes at lipid to nanoparticle ratios (L:N) of 25,000:1, 10,000:1, and 5,000:1. D-LNA structure was investigated by cryogenic transmission electron microscopy, and lipid bilayer permeability and phase behavior were investigated based on the leakage of a model drug, carboxyfluorescein, and by differential scanning calorimetry, respectively. The presence of bilayer nanoparticles caused changes in the lipid bilayer release and phase behavior compared to pure lipid controls at very low nanoparticle to bilayer volume fractions (0.3%-4.6%). Arrhenius plots of the thermal leakage show that GNP2 led to greater increases in the leakage energy barrier compared to GNP4, consistent with GNP4 causing greater bilayer disruption due to their size relative to the bilayer thickness. Embedding hydrophobic nanoparticles as permeability modifiers is a unique approach to controlling liposomal leakage based on nanoparticle size and concentration.
机译：理解的特点和脂质双层的行为嵌入纳米颗粒的作用是将含脂质的纳米颗粒组合件（低噪声放大器），用于生物医学应用的发展是至关重要的。在这项工作中，我们调查疏水性纳米颗粒的大小和浓度对脂质体热释放行为的影响。饰的LNA（d-的LNA）通过嵌入形成2纳米（GNP2）和4纳米（GNP4）十二烷硫醇封端的在脂质与纳米颗粒比（L：N）金纳米颗粒成DPPC脂质体25,000：1，10,000：1，和5000：1。通过低温透射电子显微镜d-LNA结构进行了研究，并脂质双层的渗透性和相行为进行了研究分别基于模型药物，羧基的泄漏，并且通过差示扫描量热法，。双层纳米颗粒的存在引起的在非常低的纳米粒子双层体积分数（0.3％-4.6％）相比，纯脂质控制在脂质双层中释放和相行为的变化。的热泄漏表明GNP2导致泄漏能量势垒更大的增加相比GNP4，与GNP4造成更大破坏双层一致由于相对于该双层厚度它们的大小来Arrhenius图。嵌入疏水性纳米粒子作为渗透率调节剂是一种独特的方法，基于纳米颗粒尺寸和浓度控制脂质体的泄漏。

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