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首页> 外文期刊>Current opinion in lipidology >How HIV protease inhibitors promote atherosclerotic lesion formation.
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How HIV protease inhibitors promote atherosclerotic lesion formation.

机译：HIV蛋白酶抑制剂如何促进动脉粥样硬化病变的形成。

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摘要

PURPOSE OF REVIEW: One of the aims of this review is to summarize recent clinical approaches used to determine the role of HIV protease inhibitors in the development of cardiovascular disease. Another aim is to discuss possible molecular mechanisms whereby HIV protease inhibitors may promote atherogenesis. RECENT FINDINGS: Several clinical studies have recently used ultrasonography to demonstrate increased intimal medial thickness and alterations in the structural characteristics of epi-aortic lesions in patients receiving HIV protease inhibitors. Molecular studies have indicated that several mechanisms are likely involved in mediating the effects of protease inhibitors. Possible mechanisms include inhibition of the proteasome, increased CD36 expression in macrophage, inhibition of lipoprotein lipase-mediated lipolysis, decreased adiponectin levels, and dysregulation of the NF-kappaB pathway. SUMMARY: The currently available data strongly suggest that HIV protease inhibitors negatively impact the cardiovascular system. As is often the case with complex diseases like atherosclerosis it appears that HIV protease inhibitors affect the cardiovascular system through several distinct mechanisms by affecting various components of the arterial wall directly or indirectly by influencing lipoprotein and glucose metabolism of the body.
机译：审查的目的：审查的目的之一是总结用于确定HIV蛋白酶抑制剂在心血管疾病发展中的作用的最新临床方法。另一个目的是讨论可能的分子机制，其中HIV蛋白酶抑制剂可促进动脉粥样硬化。最近的发现：一些临床研究最近已使用超声检查来证明接受HIV蛋白酶抑制剂的患者的内膜中层厚度增加以及主动脉上皮病变的结构特征发生了变化。分子研究表明，多种机制可能参与了蛋白酶抑制剂的介导作用。可能的机制包括蛋白酶体的抑制，巨噬细胞CD36表达的增加，脂蛋白脂肪酶介导的脂解的抑制，脂联素水平的降低以及NF-κB通路的失调。摘要：目前可获得的数据强烈表明，HIV蛋白酶抑制剂会对心血管系统产生负面影响。与诸如动脉粥样硬化的复杂疾病一样，HIV蛋白酶抑制剂似乎通过几种不同的机制通过直接或间接地通过影响人体的脂蛋白和葡萄糖代谢来影响动脉壁的各种成分，从而影响心血管系统。

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