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首页> 外文期刊>Current opinion in gastroenterology >Fecal microbiota transplantation: Facts and controversies
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Fecal microbiota transplantation: Facts and controversies

机译：粪便菌群移植：事实与争议

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PURPOSE OF REVIEW: To review the current evidence on fecal microbiota transplantations (FMTs) for recurrent Clostridium difficile infections (CDIs), metabolic syndrome and inflammatory bowel disease. RECENT FINDINGS: Recently, a randomized trial confirmed the efficacy of this treatment strategy in patients with recurrent CDI. For other disorders, evidence is still limited. To date, studies have been performed to try and influence the course of metabolic syndrome and inflammatory bowel disease. SUMMARY: There is increasing interest in the role of altered microbiota in the development of a myriad of diseases. Together with new insights comes an interest in influencing this altered microbiota as a potential target for therapy. FMTs are effective against recurrent CDI, a disorder caused by disruption of the normal microbiota. Restoration of intestinal flora and thereby restoration of colonization resistance is thought to be the mechanism responsible for cure. With the developments in FMT and the extension of this treatment modality to both intestinal and extra-intestinal diseases, a new field of targeted therapy awaits. The ultimate goal is the development of powerful probiotic regimens that can replace FMT. Currently, FMT should only be given in a strict experimental setting for other conditions than CDI.
机译：审查的目的：审查有关复发性艰难梭菌感染（CDI），代谢综合征和炎症性肠病的粪便菌群移植（FMT）的最新证据。最近的发现：最近，一项随机试验证实了这种治疗策略对复发性CDI患者的疗效。对于其他疾病，证据仍然有限。迄今为止，已经进行了研究以试图影响代谢综合征和炎症性肠病的病程。摘要：人们对微生物群改变在多种疾病发展中的作用越来越感兴趣。随着新见解的出现，人们有兴趣将这种改变的微生物群作为治疗的潜在靶标。 FMT可有效抵抗CDI复发，后者是由正常微生物群破坏引起的疾病。肠道菌群的恢复，从而使定植抗性的恢复，被认为是治愈的机制。随着FMT的发展以及这种治疗方式的扩展到肠道和肠道外疾病，靶向治疗的新领域正在等待中。最终目标是开发可以替代FMT的强大益生菌方案。目前，对于CDI以外的其他条件，仅应在严格的实验条件下进行FMT。

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