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首页> 外文期刊>Current opinion in gastroenterology >Therapeutic faecal microbiota transplantation: Current status and future developments
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Therapeutic faecal microbiota transplantation: Current status and future developments

机译：粪便菌群的治疗性移植：现状和未来发展

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PURPOSE OF REVIEW: Faecal microbiota transplantation (FMT) has undergone dramatic progression over the past year and continues to evolve as knowledge of the gastrointestinal microbiota (GiMb) develops. This review summarizes therapeutic advances in FMT, latest FMT therapies and presents the potential of FMT therapeutics in other gastrointestinal and extra-intestinal conditions. RECENT FINDINGS: The GiMb is now known to have a central role in the pathogenesis of many diseases. The success of FMT in curing Clostridium difficile infection (CDI) is well established and preliminary findings in other gastrointestinal conditions are promising. Published data from over 500 CDI cases suggest that FMT is generally well tolerated with minimal side effects. The commercial potential of FMT is being explored with several products under development, including frozen GiMb extract, which has been shown highly effective in treating relapsing CDI. Such products will likely become more available in coming years and revolutionize the availability and method of delivery of GiMb. SUMMARY: Recent literature unequivocally supports the use of FMT in treating relapsing CDI. Trials are underway to determine the therapeutic potential of FMT in other conditions, particularly inflammatory bowel disease. Therapeutic FMT is a dynamic field with new and emerging indications along with ongoing developments in optimal mode of administration.
机译：审查目的：粪便微生物群移植（FMT）在过去的一年中经历了戏剧性的发展，并随着对胃肠道微生物群（GiMb）知识的发展而不断发展。这篇综述总结了FMT的治疗进展，最新的FMT疗法，并介绍了FMT疗法在其他胃肠道和肠外疾病中的潜力。最近的发现：现在已知GiMb在许多疾病的发病机理中具有重要作用。 FMT在治愈艰难梭菌感染（CDI）中的成功性已得到充分确立，在其他胃肠道疾病中的初步发现也很有希望。来自500多个CDI病例的已发布数据表明，FMT通常具有良好的耐受性，且副作用极小。 FMT的商业潜力正在开发中，包括冷冻的GiMb提取物在内的几种产品正在开发中，已证明在治疗复发性CDI中非常有效。此类产品在未来几年内可能会变得更多可用，并彻底改变GiMb的可用性和交付方式。简介：最近的文献明确支持在治疗复发性CDI中使用FMT。为了确定FMT在其他情况下（尤其是炎症性肠病）的治疗潜力，正在进行试验。治疗性FMT是一个动态领域，具有新的和正在出现的适应症以及最佳给药方式的不断发展。

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