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首页> 外文期刊>Current opinion in gastroenterology >Endoscopic diagnosis of gastrointestinal stromal cell tumors.
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Endoscopic diagnosis of gastrointestinal stromal cell tumors.

机译：胃肠道间质细胞瘤的内镜诊断。

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PURPOSE OF REVIEW: To outline the recommended course of action when a subepithelial lesion is encountered during upper endoscopy. It will focus on the endoscopic and endosonographic features common to gastrointestinal stromal tumors, and the optimal tests performed to confirm the diagnosis of a gastrointestinal stromal tumor. RECENT FINDINGS: The major recent finding of a mutation in the protooncogene c-kit which is unique to gastrointestinal stromal tumors has led to their reclassification as separate from other spindle cell tumors. Endoscopic ultrasound is a key component of the evaluation of submucosal lesions of the gastrointestinal tract, allowing determination of the wall layer of origin of the lesion and diagnostic sampling. Endosonographic features of gastrointestinal stromal tumors associated with high-risk lesions include size larger than 4-5 cm, irregular or invasive border, cystic spaces and malignant appearing lymph nodes. Endoscopic ultrasound-guided fine needle aspiration is generally adequate for tissue acquisition. Immunohistochemical analysis is performed on the tissue to differentiate gastrointestinal stromal tumors from other spindle cell neoplasms. SUMMARY: The clinical behavior of gastrointestinal stromal tumors is variable. Accurate preoperative endoscopic characterization of the lesion with fine needle aspiration is critical for treatment decisions and for an assessment of prognosis.
机译：审查目的：概述在上内窥镜检查过程中遇到上皮下病变时的推荐措施。它将侧重于胃肠道间质瘤常见的内窥镜和超声检查特征，并进行最佳测试以确认对胃肠道间质瘤的诊断。最近的发现：最近在胃肠癌基质肿瘤中特有的原癌基因c-kit突变中发现了它们的重分类，使其与其他纺锤状细胞肿瘤分开。内窥镜超声检查是评估胃肠道粘膜下病变的关键因素，可以确定病变起源壁并进行诊断性采样。与高危病灶相关的胃肠道间质瘤的超声内镜特征包括大小大于4-5 cm，边界不规则或侵入性，囊性间隙和恶性淋巴结。内窥镜超声引导下的细针抽吸通常足以进行组织采集。在组织上进行免疫组织化学分析，以区分胃肠道间质瘤与其他梭形细胞肿瘤。摘要：胃肠道间质瘤的临床行为是可变的。精确的术前细针穿刺术对病变进行准确的术前内窥镜表征对于治疗决策和评估预后至关重要。

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