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首页> 外文期刊>Current opinion in infectious diseases >Receptor for advanced glycation end products in bacterial infection: Is there a role for immune modulation of receptor for advanced glycation end products in the treatment of sepsis?
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Receptor for advanced glycation end products in bacterial infection: Is there a role for immune modulation of receptor for advanced glycation end products in the treatment of sepsis?

机译：细菌感染中晚期糖基化终末产物的受体：在晚期脓毒症的治疗中，免疫调节晚​​期糖基化终末产物的受体是否有作用？

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Purpose of review: Sepsis is still associated with excess morbidity and mortality worldwide, despite significant advances in critical care medicine. A novel approach is needed in the treatment of sepsis, one that will aim to correct the specific immunologic imbalance that is detrimental to the septic host. Recent findings: As receptor for advanced glycation end products (RAGE) is involved in diverse cellular mechanisms that to a lesser or greater extent participate in the septic process, modulating its function could favorably affect outcome. Altering RAGE may result in regulating the release of proinflammatory cytokines, controlling apoptosis or modifying endothelial architecture. In that regard, several strategies have been used to study RAGE deficiency in experimental models of sepsis including antibodies against RAGE, genetically deleted RAGE knockouts, siRNA to silence RAGE, soluble forms of RAGE, and antibodies and inhibitors directed toward RAGE ligands, such as HMGB1 and S100 proteins. Summary: These studies thus far have yielded inconsistent results as to whether RAGE is beneficial or not to the host response during bacterial infection and sepsis.
机译：审查目的：尽管重症监护医学取得了重大进展，败血症仍与全世界的高发病率和高死亡率相关。在脓毒症的治疗中需要一种新的方法，其目的是纠正对败血症宿主有害的特异性免疫学失衡。最新发现：由于晚期糖基化终产物（RAGE）的受体参与了多种细胞机制，这些机制或多或少地参与了败血症过程，因此调节其功能可能会对结果产生有利影响。改变RAGE可导致调节促炎细胞因子的释放，控制细胞凋亡或改变内皮结构。在这方面，已经使用了几种策略来研究脓毒症实验模型中的RAGE缺乏症，包括针对RAGE的抗体，基因缺失的RAGE基因敲除，沉默RAGE的siRNA，RAGE的可溶性形式以及针对RAGE配体的抗体和抑制剂，例如HMGB1和S100蛋白。摘要：迄今为止，这些研究在细菌感染和败血症期间RAGE是否对宿主反应有益还是不一致的结果。

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