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首页> 外文期刊>Current opinion in lipidology >New insights and therapies for the metabolic consequences of Alstrom syndrome.
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New insights and therapies for the metabolic consequences of Alstrom syndrome.

机译：Alstrom综合征代谢后果的新见解和疗法。

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摘要

PURPOSE OF REVIEW: Recent studies have begun to evaluate the heterogeneity of insulin resistance in syndromes associated with type 2 diabetes, dyslipidaemia and associated cardiac, renal and hepatic consequences. These insights are of particular importance in Alstrom syndrome in which all of these conditions coexist from a young age with considerable morbidity and reduction in life expectancy. Clear definition of the phenotype in the syndrome may clarify biochemical pathways of crucial importance in propensity to diabetic complications and heart disease in the general population. This review will focus on ways in which more effective treatments can be put in place for Alstrom families from childhood and adolescence. RECENT FINDINGS: Studies of body fat distribution, insulin resistance, glucose metabolism and dyslipidaemia in Alstrom syndrome will be discussed as well as genotypic and phenotypic variation in the syndrome in the context of recent metabolic studies in insulin resistance. Potential therapies including low-carbohydrate diet, niaspan and incretins will be considered. SUMMARY: These new insights will encourage early introduction of protective nutrition, exercise and drug therapies in Alstrom syndrome and suggest novel approaches to understanding diabetes mellitus, hyperlipidaemias and heart disease in the general population.
机译：审查的目的：最近的研究已开始评估与2型糖尿病，血脂异常以及相关的心脏，肾脏和肝脏后果相关的综合征中胰岛素抵抗的异质性。这些见解在Alstrom综合征中特别重要，在Alstrom综合征中，所有这些疾病从年轻时就并存，并且发病率很高，并且预期寿命缩短。综合征中表型的明确定义可以阐明在一般人群中糖尿病并发症和心脏病倾向中至关重要的生化途径。这篇综述将侧重于从儿童和青春期开始为Alstrom家庭提供更有效治疗的方法。最近的发现：在最近的胰岛素抵抗代谢研究的背景下，将讨论Alstrom综合征中人体脂肪分布，胰岛素抵抗，葡萄糖代谢和血脂异常的研究，以及该综合征的基因型和表型变异。可能的疗法包括低碳水化合物饮食，尼克斯潘和肠降血糖素。摘要：这些新见解将鼓励在Alstrom综合征中尽早引入保护性营养，运动和药物疗法，并为了解普通人群中的糖尿病，高血脂和心脏病提供新的方法。

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