...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Current opinion in lipidology >Apoprotein A-I mimetic peptides and their potential anti-atherogenic mechanisms of action.
【24h】

Apoprotein A-I mimetic peptides and their potential anti-atherogenic mechanisms of action.

机译：载脂蛋白A-1模拟肽及其潜在的抗动脉粥样硬化作用机制。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

PURPOSE OF REVIEW: Peptides that resemble in physicochemical properties the helices of apoprotein A-I, the major protein of atheroprotective HDL, show promise for the treatment of atherosclerosis-related vascular disease. The properties and promise of these so-called mimetic peptides will be explored in this review. RECENT FINDINGS: Both HDL and mimetic peptides are able to scavenge and sequester oxidized lipids and hence protect endothelial cells and arteries from the pro-inflammatory action of oxidized LDL. Active mimetic peptides have an amphipathic alpha-helical secondary structure, whose hydrophobic face is particularly important for its bioactivity. The most frequently employed peptide is 4F. The comparative bioactivity of variants of 4F, particularly tandem helical peptides, has been explored. The recent observation of the very high affinity of bioactive peptides for oxidized fatty acids and phospholipids provides a likely mechanism for the action of these peptides in inhibiting early atherosclerosis formation. It is not clear that these peptides alone are effective in reversing established atherosclerosis, although they may achieve this outcome in synergy with statin therapy. SUMMARY: Recent observations of mimetic peptides have pointed to promising therapies for patients with cardiovascular disease. The peptides appear to be well tolerated and effective in promoting the anti-inflammatory properties of HDL.
机译：审查的目的：在物理化学性质上类似于载脂蛋白A-1（抗动脉粥样硬化的HDL的主要蛋白）的螺旋的肽显示出有望用于治疗与动脉粥样硬化相关的血管疾病。在这篇综述中将探讨这些所谓的模拟肽的特性和前景。最近的发现：HDL和模拟肽都能够清除和隔离氧化脂质，从而保护内皮细胞和动脉免受氧化LDL的促炎作用。活性模拟肽具有两亲性的α-螺旋二级结构，其疏水面对其生物活性尤为重要。最常用的肽是4F。已经研究了4F变体，特别是串联螺旋肽的比较生物活性。生物活性肽对氧化的脂肪酸和磷脂的极高亲和力的最新观察结果为这些肽抑制早期动脉粥样硬化的形成提供了可能的机制。尚不清楚这些肽是否单独可以有效逆转已建立的动脉粥样硬化，尽管它们可以与他汀类药物疗法协同增效。摘要：模拟肽的最新观察结果指出，心血管疾病患者有望获得有希望的治疗。该肽似乎具有良好的耐受性，并且在促进HDL的抗炎特性方面有效。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号