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首页> 外文期刊>Current opinion in lipidology >Microsomal triglyceride transfer protein inhibition: a novel treatment for lowering plasma cholesterol.
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Microsomal triglyceride transfer protein inhibition: a novel treatment for lowering plasma cholesterol.

机译：微粒体甘油三酸酯转移蛋白抑制：降低血浆胆固醇的新方法。

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BJUT-II VAD (Beijing University of Technology ventricular assist device II) is a novel left ventricular assist device. Because of the special connection between the pump and native heart, the hemodynamic effects of BJUT-II VAD on coronary artery are still unclear. Hence, numerical simulations have been conducted to clarify changes in hemodynamic effects of different support modes. A patient-specific left coronary arterial geometric model is reconstructed based on the computed tomography (CT) data. Three support modes, "constant speed mode," "co-pulse mode," and "counter pulse mode," are used in this study. The wall shear stress (WSS), wall shear stress gradient (WSSG), cycle-averaged wall shear stress (avWSS), oscillatory shear index (OSI), and the flow pattern are calculated to evaluate the hemodynamic states of coronary artery. The computational results demonstrate that the hemodynamic states of coronary artery are directly affected by the support modes. The co-pulse modes could achieve the highest blood perfusion (constant speed: 153 ml/min vs. co-pulse: 775 ml/min vs. counter pulse: 140 ml/min) and the highest avWSS (constant speed: 18.1 Pa vs. co-pulse: 42.6 Pa vs. counter pulse: 22.6 Pa). In addition, both the WSS and WSSG at the time of peak blood velocity under the constant speed mode are lower than those under other two support modes. In contrast, the counter pulse mode generates the highest OSI value (constant speed: 0.365 vs. co-pulse: 0.379 vs. counter pulse: 0.426). BJUT-II VAD under co-pulse mode may have benefits for improving coronary perfusion and preventing the development of atherosclerosis; however, the constant speed mode may have benefit for preventing the development of plaque vulnerability.
机译：BJUT-II VAD（北京工业大学心室辅助设备II）是一种新型的左心室辅助设备。由于泵和天然心脏之间的特殊连接，因此尚不清楚BJUT-II VAD对冠状动脉的血流动力学影响。因此，已经进行了数值模拟以阐明不同支持模式的血液动力学效应的变化。根据计算机断层扫描（CT）数据重建患者特定的左冠状动脉几何模型。在这项研究中使用了三种支持模式，即“恒定速度模式”，“同脉冲模式”和“反脉冲模式”。计算壁切应力（WSS），壁切应力梯度（WSSG），循环平均壁切应力（avWSS），振荡剪切指数（OSI）和流动模式，以评估冠状动脉的血流动力学状态。计算结果表明，支持方式直接影响了冠状动脉的血流动力学状态。同脉冲模式可以实现最高的血液灌注（恒定速度：153 ml / min vs.同脉冲：775 ml / min与反脉冲：140 ml / min）和最高的avWSS（恒定速度：18.1 Pa vs共脉冲：42.6 Pa，反脉冲：22.6 Pa）。另外，在恒速模式下的峰值血流速度时的WSS和WSSG均低于其他两种支持模式下的WSS和WSSG。相反，反脉冲模式产生最高的OSI值（恒定速度：0.365 vs.同脉冲：0.379 vs.反脉冲：0.426）。脉冲模式下的BJUT-II VAD可能有益于改善冠状动脉灌注和预防动脉粥样硬化的发展;但是，恒速模式可能有助于防止牙菌斑的发生。

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