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Progress in genetics of plasma lipids: Tapped out or pausing for second wind?

机译:血浆脂类遗传学的进展:挖掘还是暂停第二次风?

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摘要

The first genome-wide association studies (GWASs) of plasma lipids emerged about 7 years ago [1]. These initial efforts were carried out in relatively small samples of a few thousand individuals and were performed using early micorarrays that could genotype ~100000 single-nucleotide polymorphisms (SNPs). Although they yielded few significant findings, the first-generation GWASs signaled that much larger sample sizes were required in order to detect the very modest effects of genetic variants on plasma lipids, especially in epidemiological cohorts that were predominantly normolipidemic.
机译:大约7年前出现了关于血浆脂质的第一个全基因组关联研究(GWAS)。这些最初的工作是在几千个个体的相对较小的样本中进行的,并且使用了早期的微阵列进行,这些微阵列可以对约100000个单核苷酸多态性(SNP)进行基因分型。尽管他们获得的重要发现很少,但是第一代GWAS信号表明需要更大的样本量才能检测出遗传变异对血脂的适度影响,尤其是在主要为高血脂的流行病学队列中。

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