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首页> 外文期刊>Current opinion in lipidology >Class A scavenger receptors, macrophages, and atherosclerosis.
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Class A scavenger receptors, macrophages, and atherosclerosis.

机译：A类清除剂受体，巨噬细胞和动脉粥样硬化。

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The scope of this review is to discuss the new advances in our understanding of the role of scavenger receptor class A in the initiation and modulation of the atherosclerotic process. Through the approaches of gene manipulation in the mouse model, a substantial body of literature has accumulated that depicts scavenger receptor class A as a central player in atherogenesis. In studies of scavenger receptor class A overexpression in macrophages through bone marrow transplantation using transgenic donor material, recipient mice with hyperlipidemia caused either by apolipoprotein E or LDL receptor deficiency did not show convincing changes in the degree of atherosclerosis development compared with controls. Conversely, the deletion of the scavenger receptor class A gene in the mouse has shown, in a consistent and significant fashion, that this receptor serves a pro-atherogenic function under hyperlipidemic conditions, as both apolipoprotein E and LDL receptor-deficient mice had reduced atherosclerosis in the absence of scavenger receptor class A. In addition, we have recently shown that C57BL/6 mice are protected from diet-induced atherosclerosis when they lack scavenger receptor class A, and that the macrophage is the cell type responsible for the effect of scavenger receptor class A deficiency in reducing lesion formation in C57BL/6 and LDL receptor null mice. Together, these results demonstrate that macrophage scavenger receptor class A contributes significantly to atherosclerotic lesion formation, and suggest that the uptake of oxidized or modified lipoproteins by vessel wall macrophages is a central process in atherogenesis.
机译：这篇综述的范围是讨论我们对清除剂受体A类在动脉粥样硬化过程的起始和调节中的作用的理解的新进展。通过在小鼠模型中进行基因操纵的方法，积累了大量文献，这些文献将清道夫受体A类描述为动脉粥样硬化的主要参与者。在通过使用转基因供体材料的骨髓移植通过巨噬细胞清道夫受体A类过表达的研究中，由载脂蛋白E或LDL受体缺乏引起的高脂血症受体小鼠与对照相比没有令人信服的动脉粥样硬化发展程度变化。相反，小鼠中清道夫受体A类基因的缺失以一致且重要的方式表明，该受体在高脂血症条件下具有促动脉粥样硬化的功能，因为载脂蛋白E和LDL受体缺陷型小鼠均具有降低的动脉粥样硬化此外，我们最近还表明，当C57BL / 6小鼠缺乏清除剂受体A类时，可以免受饮食诱导的动脉粥样硬化的侵害，并且巨噬细胞是负责清除剂作用的细胞类型在减少C57BL / 6和LDL受体缺失小鼠的病变形成中的A类受体缺乏症。总之，这些结果表明，巨噬细胞清道夫受体A类显着促进了动脉粥样硬化病变的形成，并表明血管壁巨噬细胞对氧化或修饰的脂蛋白的摄取是动脉粥样硬化发生的主要过程。

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