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首页> 外文期刊>Current stem cell research & therapy >Applications of human umbilical cord blood cells in central nervous system regeneration.
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Applications of human umbilical cord blood cells in central nervous system regeneration.

机译：人脐带血细胞在中枢神经系统再生中的应用。

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摘要

In recent decades, there has been considerable amount of information about embryonic stem cells (ES). The dilemma facing scientists interested in the development and use of human stem cells in replacement therapies is the source of these cells, i.e. the human embryo. There are many ethical and moral problems related to the use of these cells. Hematopoietic stem cells from umbilical cord blood have been proposed as an alternative source of embryonic stem cells. After exposure to different agents, these cells are able to express antigens of diverse cellular lineages, including the neural type. The In vitro manipulation of human umbilical cord blood (hUCB) cells has shown their stem capacity and plasticity. These cells are easily accessible, In vitro amplifiable, well tolerated by the host, and with more primitive molecular characteristics that give them great flexibility. Overall, these properties open a promising future for the use of hUCB in regenerative therapies for the Central Nervous System (CNS). This review will focus on the available literature concerning umbilical cord blood cells as a therapeutic tool for the treatment of neurodegenerative diseases.
机译：在最近的几十年中，已经有了关于胚胎干细胞（ES）的大量信息。对人类干细胞在替代疗法中的开发和使用感兴趣的科学家所面临的困境是这些细胞，即人类胚胎的来源。存在与使用这些电池有关的许多道德和道德问题。已经提出了来自脐带血的造血干细胞作为胚胎干细胞的替代来源。暴露于不同的药物后，这些细胞能够表达多种细胞谱系的抗原，包括神经型。人脐带血（hUCB）细胞的体外操作显示出它们的干细胞能力和可塑性。这些细胞易于获取，体外扩增，宿主耐受性好，并具有更原始的分子特性，因此具有极大的灵活性。总体而言，这些特性为hUCB在中枢神经系统（CNS）再生治疗中的应用打开了广阔的前景。这篇综述将集中在有关脐血细胞作为治疗神经退行性疾病的治疗工具的现有文献上。

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