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Gastric motor and sensory function.

机译：胃运动和感觉功能。

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摘要

PURPOSE OF REVIEW: Abnormalities of gastric sensory and motor function are considered key players in the pathogenesis of upper gastrointestinal symptoms in functional dyspepsia and in gastroparesis. This review summarizes recent progress in our understanding of gastric sensory and motor function in health and in disease. RECENT FINDINGS: Although assessment of gastric emptying rate is often used in the clinical work-up of patients with functional dyspepsia or gastroparesis, the correlation with symptoms is generally poor. Central processing, related to psychosocial dysfunction, is increasingly implicated in the pathogensis of gastric hypersensitivity. Meal challenge test and in fact even simple ingestion of a meal induce increased symptom occurrence in functional dyspepsia. Impaired motor function in critically ill patients is increasingly being studied and recognized as a prognostically relevant factor. Studies have reported on pharmacological approaches as well as electrical stimulation in the treatment of gastric sensorimotor dysfunction. SUMMARY: Progress in our understanding of the normal and abnormal gastric sensory and motor function may lead to new or improved treatment modalities. Areas of recent advances are the role of the central nervous system in visceral hypersensitivity, motor abnormalities of the stomach in critically ill patients and the exploration of novel pharmacotherapeutic approaches.
机译：审查的目的：胃感觉和运动功能异常被认为是功能性消化不良和胃轻瘫中上消化道症状发病机理的关键因素。这篇综述总结了我们对健康和疾病中的胃感觉和运动功能的理解的最新进展。最近的发现：尽管在功能性消化不良或胃轻瘫患者的临床检查中经常使用胃排空率的评估，但与症状的相关性通常较差。与社会心理功能障碍有关的中央处理越来越多地涉及胃过敏症的病因。进餐挑战测试，实际上甚至是简单进餐，都会引起功能性消化不良症状的增加。危重患者运动功能受损的研究越来越多，并被认为是预后相关因素。研究已经报道了在治疗胃感觉运动功能障碍方面的药理学方法以及电刺激。摘要：我们对正常和异常胃部感觉和运动功能的了解可能会导致新的或改善的治疗方式。最新进展的领域是中枢神经系统在内脏超敏反应，危重患者胃部运动异常以及新型药物治疗方法中的作用。

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