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首页> 外文期刊>Current opinion in gastroenterology >Gastroduodenal mucosal defense: an integrated protective response
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Gastroduodenal mucosal defense: an integrated protective response

机译：胃十二指肠粘膜防御：综合保护反应

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The remarkable resistance of the mucosal lining the upper gastrointestinal tract to concentrated gastric acid remains one of the biggest unsolved mysteries of upper gastrointestinal physiology. Even with the discovery of the involvement of Helicobacter pylori in gastroduodenal injury, the mechanism by which the organism causes injury remains unresolved. In the past year, there have been striking findings regarding trefoil peptides, the protective effect of regulatory peptides such as adrenomedullin, and the influence of H. pylori on the junctions that join the epithelial cells.Peptic ulcer disease, although declining in prevalence, appears to be increasing in virulence, perhaps because of the overall aging of the population and improved intensive care unit care. Although H. pylori and nonsteroidal anti-inflammatory drugs have been identified as key pro-ulcerogenic factors, many ulcers may also result from a deficiency of other, unknown host protective factors. A more detailed understanding of the host factors involved in mucosal protection will thus help identify novel therapeutic targets aimed at the prevention and treatment of upper gastrointestinal mucosal injury.
机译：上消化道粘膜衬里对浓胃酸的显着抵抗仍然是上消化道生理学最大的未解之谜之一。即使发现幽门螺杆菌参与胃十二指肠损伤，该微生物引起损伤的机制仍未解决。在过去的一年中，关于三叶肽，调节肽（如肾上腺髓质素）的保护作用以及幽门螺杆菌对连接上皮细胞的连接点的影响，发现了惊人的发现。毒力不断增加，可能是由于人口的整体老龄化和重症监护病房的改善。尽管幽门螺杆菌和非甾体类抗炎药已被确定为促溃疡的关键因素，但许多其他未知宿主保护因子的缺乏也可能导致许多溃疡。因此，对涉及粘膜保护的宿主因素的更详细的了解将有助于确定旨在预防和治疗上消化道粘膜损伤的新治疗靶标。

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