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首页> 外文期刊>Current opinion in gastroenterology >Immunonutrition: can you be what you eat?
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Immunonutrition: can you be what you eat?

机译：免疫营养：你能吃点东西吗？

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摘要

Some nutrients also influence immunologic responses. Those that have been putatively identified as having such properties include glutamine,ω3 fatty acids, arginine, and ribonucleic acid. Use of these immunonutrients in nutrition support has become known as "immunonutrition." Three of these substances (no data for ribonucleic acid) have been evaluated as individual supplements in randomized controlled trials; for the most part, no clinical efficacy was established. Different combinations of these nutrients have been added to standard enteral nutrition support solutions to create several commercial products. Randomized, controlled trials have suggested that recipients of these commercial immunonutrition formulas had better outcomes than controls receiving standard enteral nutrition. However, a number of design and execution problems with many of those trials exist. Furthermore, we do not have sufficient data to determine if the beneficial effects that have been observed result from a pharmacologic effect of the immunonutrient or to the entire nutrition support regimen. Because an immunonutrient can either upregulate or downregulate the immune response, any effect that is seen may be disease State specific.
机译：一些营养素也会影响免疫反应。被推定为具有这种性质的物质包括谷氨酰胺，ω3脂肪酸，精氨酸和核糖核酸。在营养支持中使用这些免疫营养素已被称为“免疫营养”。其中的三种物质（无核糖核酸数据）已在随机对照试验中作为单独的补充剂进行了评估;在大多数情况下，尚无临床疗效。这些营养素的不同组合已添加到标准肠内营养支持解决方案中，以生产几种商业产品。随机对照试验表明，这些商业免疫营养配方食品的接受者比接受标准肠内营养的对照组具有更好的结局。但是，其中许多试验存在许多设计和执行问题。此外，我们没有足够的数据来确定观察到的有益效果是否是免疫营养素的药理作用还是整个营养支持方案的结果。由于免疫营养素可以上调或下调免疫反应，因此所见到的任何效应可能是疾病状态所特有的。

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