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首页> 外文期刊>Current opinion in gastroenterology >Immunologic regulation of toll-like receptors in gut epithelium
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Immunologic regulation of toll-like receptors in gut epithelium

机译：肠上皮中Toll样受体的免疫学调节

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摘要

In response to the presence of pathogens in the environment, the innate immune system has evolved to provide a rapid defense against microbes. This response involves the recognition of molecular patterns present in diverse microbes by a series of receptors termed toll-like receptors. The focus of this article is the regulation of toll-like receptor signaling in the intestinal epithelium. The intestinal epithelium is continually exposed to a high concentration of diverse bacteria. In spite of the density of commensal bacteria, the normal intestine is not inflamed. Idiopathic inflammatory bowel disease in humans and animals is characterized by aberrant host-microbial interactions.The intestinal epithelium has evolved under the pressure of the microbiota to mute a response to commensal bacteria while maintaining the ability to respond to pathogens. In inflammatory bowel disease, the loss of tolerance to the normal flora may be due in part to inappropriate toll-like receptor signaling.
机译：为了响应环境中病原体的存在，先天免疫系统已经进化为提供对微生物的快速防御。这种反应包括被称为“ toll样受体”的一系列受体识别各种微生物中存在的分子模式。本文的重点是肠上皮中Toll样受体信号的调节。肠上皮持续暴露于高浓度的各种细菌中。尽管共生细菌的密度很大，但正常肠道并未发炎。人类和动物的特发性炎症性肠病的特征是宿主与微生物之间的相互作用异常。肠道上皮细胞在微生物群的压力下进化，以减弱对共生细菌的反应，同时保持对病原体的反应能力。在炎性肠病中，对正常菌群的耐受性丧失可能部分归因于不适当的收费样受体信号传导。

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