TET2 and DNMT3A mutations in human T-cell lymphoma.

Couronne L; Bastard C; Bernard OA

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TET2 and DNMT3A mutations in human T-cell lymphoma.

机译：TET2和DNMT3A在人T细胞淋巴瘤中的突变。

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to the editor: Despite the poor prognosis of T-cell lymphomas, the genetic basis of these cancers is poorly defined. We have found acquired TET2 mutations in both human myeloid cancers and T-cell lymphoma. TET proteins are involved in the epigenetic control of transcription, at least through the oxidation of methylated cytosines and DNA demethylation.The catalytic activity of the TET proteins is inhibited by 2-hydroxygluta-rate, an oncogenic metabolite produced by the mutated forms of the IDH1 and IDH2 enzymes.

机译：对于编辑：尽管T细胞淋巴瘤预后差，但这些癌症的遗传基础定义不足。我们发现了人髓样癌和T细胞淋巴瘤中获得的TET2突变。 TET蛋白参与转录的表观遗传控制，至少通过甲基化胞嘧啶和DNA去甲基化氧化。TET蛋白的催化活性被2-羟基凝集率抑制，由IDH1的突变形式产生的致癌代谢物和IDH2酶。

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《The New England journal of medicine》 |2012年第1期|共2页
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Couronne L; Bastard C; Bernard OA;
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1. TET2 and DNMT3A mutations in human T-cell lymphoma. [J] . Couronne L, Bastard C, Bernard OA The New England journal of medicine . 2012,第1期

机译：TET2和DNMT3A在人T细胞淋巴瘤中的突变。
2. TET2 and DNMT3A mutations in human T-cell lymphoma. [J] . Couronne L, Bastard C, Bernard OA The New England journal of medicine . 2012,第1期

机译：TET2和DNMT3A在人T细胞淋巴瘤中的突变。
3. TET2 Mutation in Adult T-Cell Leukemia/Lymphoma. [J] . Kazuya Shimoda, Kotaro Shide, Takuro Kameda, Journal of clinical and experimental hematopathology : . 2015,第3期

机译：成人T细胞白血病/淋巴瘤中的TET2突变。
4. New biologic agents for the treatment of cutaneous T-cell lymphoma. [C] . Vittorio CC, Junkins Hopkins JM, McGinnis KS, World Congress on Cancers of the Skin . 2002

机译：用于治疗皮肤T细胞淋巴瘤的新生物剂。
5. Molecular characterization of HTLV-I integration sites in patients with adult T-cell leukemia/lymphoma. [D] . Kemper, Robert Russell, Jr. 1994

机译：成人T细胞白血病/淋巴瘤患者HTLV-1整合位点的分子特征。
6. Thrombotic Risk Detection in Patients with Polycythemia Vera: The Predictive Role of DNMT3A/TET2/ASXL1 Mutations [O] . Adrián Segura-Díaz, Ruth Stuckey, Yanira Florido, 2020

机译：真性红细胞增多症患者的血栓风险检测：DNMT3A / TET2 / ASXL1突变的预测作用
7. TET2 and DNMT3A mutations and exceptional response to 4′-thio-2′-deoxycytidine in human solid tumor models [O] . Sherry X. Yang, Melinda Hollingshead, Larry Rubinstein, 2021

机译：TET2和DNMT3A突变和对4'-THIO-2'-脱氧胞苷的卓越反应在人体固体肿瘤模型中

TET2 and DNMT3A mutations in human T-cell lymphoma.

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