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Effects of ubiquinone (coenzyme Q10) on myopathy in statin users.

机译：泛醌（辅酶Q10）对他汀类药物使用者肌病的影响。

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PURPOSE OF REVIEW: Statins are associated with muscle complaints, including myositis. The mechanism through which statin use causes muscle toxicity is unknown. One of the theories is that statin therapy reduces coenzyme Q10 levels in muscle mitochondria, which leads to muscle injury and myopathy. The aim of the present article is to review published data on the association between coenzyme Q10 and statin-associated myopathy. RECENT FINDINGS: Studies have consistently shown that statins reduce coenzyme Q10 levels in serum and that supplementation of coenzyme Q10 increases these levels. However, the effect of statin therapy on coenzyme Q10 levels in muscle has been conflicting. Recently, two pilot studies on coenzyme Q10 supplementation in statin-induced myopathy and one study on the effect of coenzyme Q10 supplementation on serum muscle enzyme levels were published. These three studies were the first randomized trials with coenzyme Q10 supplementation in hypercholesterolemic patients treated with statins. The results of these trials have been contradictory; whereas one seems to support supplementation with coenzyme Q10, the other two do not. SUMMARY: This review summarizes the current evidence on coenzyme Q10 supplementation in statin-induced myopathy. We conclude that the present evidence does not support coenzyme Q10 supplementation in statin-induced myopathy.
机译：审查目的：他汀类药物与包括肌炎在内的肌肉疾病有关。他汀类药物使用引起肌肉毒性的机制尚不清楚。一种理论是他汀类药物疗法可降低线粒体肌肉中的辅酶Q10水平，从而导致肌肉损伤和肌病。本文的目的是审查有关辅酶Q10与他汀类药物相关的肌病之间关联的公开数据。最近的发现：研究一致表明他汀类药物会降低血清中辅酶Q10的水平，补充辅酶Q10会增加这些水平。然而，他汀类药物疗法对肌肉中辅酶Q10水平的影响一直存在矛盾。最近，发表了两项补充他汀类药物引起的肌病的辅酶Q10的先导研究和一项补充辅酶Q10对血清肌酶水平影响的研究。这三项研究是首次在接受他汀类药物治疗的高胆固醇血症患者中添加辅酶Q10的随机试验。这些试验的结果是矛盾的。而其中一个似乎支持补充辅酶Q10，而另两个则不支持。摘要：这篇综述总结了补充他汀类药物引起的肌病的辅酶Q10的现有证据。我们得出结论，目前的证据不支持他汀类药物诱发的肌病中辅酶Q10的补充。

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