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首页> 外文期刊>Current opinion in lipidology >Pregnancy in women suffering from familial hypercholesterolemia: a harmful period for both mother and newborn?
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Pregnancy in women suffering from familial hypercholesterolemia: a harmful period for both mother and newborn?

机译：患有家族性高胆固醇血症的妇女的怀孕：对母亲和新生儿都有害吗？

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PURPOSE OF REVIEW: The present review aims to highlight the consequences for mother and child of profound hypercholesterolemia during pregnancy of women with familial hypercholesterolemia. RECENT FINDINGS: Familial hypercholesterolemia is increasingly diagnosed in younger patients due to the existence of screening programs and more widespread cholesterol testing. Increasing numbers of young female patients with familial hypercholesterolemia raise the issue of pregnancy and its consequences for the familial hypercholesterolemia patient herself but also for her offspring. When pregnancy is considered, lipid-lowering drugs are often discontinued because of the fear for teratogenic effects. The evidence for teratogenesis associated with statin use is scant and conflicting. On the other hand, several studies do suggest that pronounced hypercholesterolemia during pregnancy has adverse effects on both fetus and mother. In fact, human and animal studies reveal an enhanced tendency toward atherosclerosis in the offspring of women who suffer from hypercholesterolemia during pregnancy. In animal studies, some evidence exists that this can be reversed by treatment with lipid-lowering and antioxidative agents. Until today, however, no human studies exist that have evaluated efficacy or safety of lipid-lowering interventions in pregnant women with familial hypercholesterolemia. SUMMARY: Altogether, the suggested relationship between severe hypercholesterolemia and enhanced atherosclerosis in offspring and possibly the mother warrants further confirmation and, consequently, studies that focus on therapeutic strategies that can safely lower cholesterol levels during pregnancy in these women.
机译：综述的目的：本综述旨在强调家族性高胆固醇血症妇女在妊娠期间严重母体高胆固醇血症对母亲和孩子的影响。最近的发现：由于存在筛查程序和更广泛的胆固醇测试，在年轻患者中越来越多地诊断出家族性高胆固醇血症。患有家族性高胆固醇血症的年轻女性患者数量的增加引发了怀孕问题及其对家族性高胆固醇血症患者本身及其后代的影响。考虑怀孕时，由于担心会引起致畸作用，因此通常停止使用降脂药。与他汀类药物使用相关的致畸作用的证据很少且相互矛盾。另一方面，一些研究确实表明，怀孕期间明显的高胆固醇血症对胎儿和母亲都有不利影响。实际上，人类和动物研究显示，怀孕期间患有高胆固醇血症的女性后代的动脉粥样硬化趋势增强。在动物研究中，存在一些证据表明可以通过使用降脂和抗氧化剂治疗来逆转这种情况。然而，直到今天，尚无人类研究评估降脂干预措施对家族性高胆固醇血症孕妇的疗效或安全性。摘要：总体而言，后代甚至母亲可能患有严重的高胆固醇血症和动脉粥样硬化的建议关系值得进一步证实，因此，研究侧重于可以安全地降低这些妇女怀孕期间胆固醇水平的治疗策略的研究。

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