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首页> 外文期刊>Current opinion in lipidology >Variation in paraoxonase-1 activity and atherosclerosis.
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Variation in paraoxonase-1 activity and atherosclerosis.

机译：对氧磷酶1活性和动脉粥样硬化的变化。

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PURPOSE OF REVIEW: Paraoxonase-1 (PON1) is an HDL-associated protein of 354 amino acids with a molecular mass of 43 000 Da. It is synthesized in the liver, and in serum it is almost exclusively associated with HDL. PON1 has been reported to be an important contributor to the antioxidant and anti-inflammatory activities of HDL. PON1 impedes oxidative modification of LDL. PON1 serum activity is related to systemic lipid peroxidation stress and prospective cardiovascular risk. In this review, we discuss the relationship between PON1 activity and atherosclerotic diseases and various factors modulating PON1 activity including genes, age, lifestyle factors and medical conditions. Finally, evidence that pharmacological agents may affect PON1 activity is summarized. RECENT FINDINGS: There is increasing evidence from both animal and human studies linking low PON1 activity to an increased likelihood of cardiovascular diseases. Two prospective studies reported a significantly lower incidence of major cardiovascular events in participants with the highest systemic PON1 activity, compared with those with the lowest activity. SUMMARY: PON1 is a potentially antiatherogenic HDL-associated enzyme that protects LDL from oxidative modification. Enhancing PON1 activity could be an important target for future pharmacological agents aimed at decreasing cardiovascular risk.
机译：审查目的：对氧磷酶-1（PON1）是一种高密度脂蛋白相关蛋白，具有354个氨基酸，分子量为43000 Da。它在肝脏中合成，在血清中几乎只与HDL相关。据报道，PON1是HDL的抗氧化和抗炎活性的重要贡献。 PON1阻碍LDL的氧化修饰。 PON1血清活性与全身脂质过氧化应激和预期的心血管风险有关。在这篇综述中，我们讨论了PON1活性与动脉粥样硬化疾病以及各种调节PON1活性的因素之间的关系，包括基因，年龄，生活方式因素和医疗状况。最后，总结了药理剂可能影响PON1活性的证据。最近的发现：来自动物和人类研究的越来越多的证据表明，PON1活性低与心血管疾病的可能性增加有关。两项前瞻性研究报道，全身性PON1活性最高的参与者与那些最低活性的PON1参与者相比，主要心血管事件的发生率显着降低。简介：PON1是一种潜在的抗动脉粥样硬化HDL相关酶，可保护LDL免受氧化修饰。增强PON1活性可能是未来旨在降低心血管疾病风险的药物的重要目标。

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