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The low-density lipoprotein receptor-related protein 1 in inflammation

机译：低密度脂蛋白受体相关蛋白1在炎症中的作用

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PURPOSE OF REVIEW: The lipoprotein receptor low-density lipoprotein receptor-related protein 1 (LRP1) functions both in endocytosis and in signal transduction. Recently, it has become clear that LRP1 modulates the inflammatory response to various noxious stimuli. This review is to summarize our current knowledge about the role of LRP1 in inflammation. RECENT FINDINGS: LRP1 modulates the inflammatory response in different organs and under various pathophysiological conditions. Both direct regulation of inflammatory signaling through the binding of extracellular messengers or intracellular signaling molecules and indirect modulation through the interaction with other transmembrane receptors or the endocytosis of extracellular factors have been described. Regulation by LRP1 effects cytokine secretion, phagocytosis and migration of cells of the immune system. SUMMARY: In recent years, LRP1 emerged as an important regulator of the inflammatory response. Owing to the ubiquitous expression of this receptor, this function is of importance in different organs and under various pathophysiological conditions in which inflammation contributes to disease, that is atherosclerosis, neurodegeneration and organ fibrosis, for example of the lung or liver. ? 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins.
机译：审查目的：脂蛋白受体低密度脂蛋白受体相关蛋白1（LRP1）在胞吞作用和信号转导中均起作用。最近，已经清楚的是，LRP1调节对各种有害刺激的炎性反应。这篇综述总结了我们目前关于LRP1在炎症中的作用的知识。最近的发现：LRP1在不同的器官和各种病理生理条件下调节炎症反应。已经描述了通过细胞外信使或细胞内信号分子的结合直接调节炎症信号，以及通过与其他跨膜受体的相互作用或细胞外因子的内吞作用间接调节炎症信号。 LRP1的调节作用会影响免疫系统细胞的细胞因子分泌，吞噬作用和迁移。摘要：近年来，LRP1成为炎症反应的重要调节剂。由于该受体的普遍表达，该功能在不同器官中以及在各种病理生理条件下都很重要，在这些条件下，炎症会导致疾病，例如动脉粥样硬化，神经变性和器官纤维化，例如肺或肝。 ？ 2013威科集团健康|利平科特·威廉姆斯和威尔金斯。

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